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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: KLB All Species: 17.27
Human Site: Y880 Identified Species: 34.55
UniProt: Q86Z14 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.27
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q86Z14 NP_783864.1 1044 119808 Y880 L R W V R R N Y G D M D I Y I
Chimpanzee Pan troglodytes XP_526550 1044 119852 Y880 L R W V R R N Y G D M D I Y I
Rhesus Macaque Macaca mulatta XP_001091413 1044 119556 Y880 L R W V R R N Y G D M D I Y I
Dog Lupus familis XP_536257 1037 119179 Y880 L R W I Q K N Y G D V D V Y I
Cat Felis silvestris
Mouse Mus musculus Q99N32 1043 120170 Y878 L A W I R R N Y R D R D I Y I
Rat Rattus norvegicus Q9Z2Y9 1014 116781 G866 N W L R F K Y G D L P M F V T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512722 1014 114479 D863 Y V T A N G V D D P D P L D D
Chicken Gallus gallus XP_423224 607 70411 D465 I T A N G I D D Q S L D N D E
Frog Xenopus laevis NP_001106299 607 69234 G465 L K A V K Y D G V D L R G Y T
Zebra Danio Brachydanio rerio XP_690797 990 113270 M848 K G V P I Y V M A N G V Q E D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_792744 548 62078 E406 L L A W I K K E Y G D L P V Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FZE0 510 58107 V368 A V S D S G T V T L P F K G L
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.2 97.1 85.5 N.A. 78.9 46.1 N.A. 67.9 41.7 25.1 42.1 N.A. N.A. N.A. N.A. 25.1
Protein Similarity: 100 99.5 98.7 91.6 N.A. 88.8 62.7 N.A. 79.1 49.5 36.6 60.5 N.A. N.A. N.A. N.A. 36.6
P-Site Identity: 100 100 100 66.6 N.A. 73.3 0 N.A. 0 6.6 26.6 0 N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 100 100 100 N.A. 80 6.6 N.A. 6.6 26.6 53.3 6.6 N.A. N.A. N.A. N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. 21.2 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 32.6 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 9 25 9 0 0 0 0 9 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 9 0 0 17 17 17 50 17 50 0 17 17 % D
% Glu: 0 0 0 0 0 0 0 9 0 0 0 0 0 9 9 % E
% Phe: 0 0 0 0 9 0 0 0 0 0 0 9 9 0 0 % F
% Gly: 0 9 0 0 9 17 0 17 34 9 9 0 9 9 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 9 0 0 17 17 9 0 0 0 0 0 0 34 0 42 % I
% Lys: 9 9 0 0 9 25 9 0 0 0 0 0 9 0 0 % K
% Leu: 59 9 9 0 0 0 0 0 0 17 17 9 9 0 9 % L
% Met: 0 0 0 0 0 0 0 9 0 0 25 9 0 0 0 % M
% Asn: 9 0 0 9 9 0 42 0 0 9 0 0 9 0 0 % N
% Pro: 0 0 0 9 0 0 0 0 0 9 17 9 9 0 0 % P
% Gln: 0 0 0 0 9 0 0 0 9 0 0 0 9 0 0 % Q
% Arg: 0 34 0 9 34 34 0 0 9 0 9 9 0 0 0 % R
% Ser: 0 0 9 0 9 0 0 0 0 9 0 0 0 0 0 % S
% Thr: 0 9 9 0 0 0 9 0 9 0 0 0 0 0 17 % T
% Val: 0 17 9 34 0 0 17 9 9 0 9 9 9 17 0 % V
% Trp: 0 9 42 9 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 9 0 0 0 0 17 9 42 9 0 0 0 0 50 9 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _