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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: KLB All Species: 16.67
Human Site: Y918 Identified Species: 33.33
UniProt: Q86Z14 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q86Z14 NP_783864.1 1044 119808 Y918 L Q E V L K A Y L I D K V R I
Chimpanzee Pan troglodytes XP_526550 1044 119852 Y918 L Q E V L K A Y L I D K V R I
Rhesus Macaque Macaca mulatta XP_001091413 1044 119556 Y918 L Q E V L K A Y L I D K V R I
Dog Lupus familis XP_536257 1037 119179 H918 I Q E A L K A H L I D K V K V
Cat Felis silvestris
Mouse Mus musculus Q99N32 1043 120170 Y916 V Q E A L K A Y L I D K V K I
Rat Rattus norvegicus Q9Z2Y9 1014 116781 Y904 V N E A L K A Y V L D G I N L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512722 1014 114479 F901 N V K G Y Y A F K L T E E K S
Chicken Gallus gallus XP_423224 607 70411 K503 V R G Y Y A F K L T E E K S K
Frog Xenopus laevis NP_001106299 607 69234 A503 N Y S D P E L A R I P K K S T
Zebra Danio Brachydanio rerio XP_690797 990 113270 L886 Y M L D A V N L K G Y F A Y A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_792744 548 62078 L444 T S Y I N E V L K A I E V D E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FZE0 510 58107 G406 N Y I K H R Y G N P P V F I T
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.2 97.1 85.5 N.A. 78.9 46.1 N.A. 67.9 41.7 25.1 42.1 N.A. N.A. N.A. N.A. 25.1
Protein Similarity: 100 99.5 98.7 91.6 N.A. 88.8 62.7 N.A. 79.1 49.5 36.6 60.5 N.A. N.A. N.A. N.A. 36.6
P-Site Identity: 100 100 100 66.6 N.A. 80 40 N.A. 6.6 6.6 13.3 0 N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 73.3 N.A. 40 33.3 20 0 N.A. N.A. N.A. N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. 21.2 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 32.6 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 25 9 9 59 9 0 9 0 0 9 0 9 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 17 0 0 0 0 0 0 50 0 0 9 0 % D
% Glu: 0 0 50 0 0 17 0 0 0 0 9 25 9 0 9 % E
% Phe: 0 0 0 0 0 0 9 9 0 0 0 9 9 0 0 % F
% Gly: 0 0 9 9 0 0 0 9 0 9 0 9 0 0 0 % G
% His: 0 0 0 0 9 0 0 9 0 0 0 0 0 0 0 % H
% Ile: 9 0 9 9 0 0 0 0 0 50 9 0 9 9 34 % I
% Lys: 0 0 9 9 0 50 0 9 25 0 0 50 17 25 9 % K
% Leu: 25 0 9 0 50 0 9 17 50 17 0 0 0 0 9 % L
% Met: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 25 9 0 0 9 0 9 0 9 0 0 0 0 9 0 % N
% Pro: 0 0 0 0 9 0 0 0 0 9 17 0 0 0 0 % P
% Gln: 0 42 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 9 0 0 0 9 0 0 9 0 0 0 0 25 0 % R
% Ser: 0 9 9 0 0 0 0 0 0 0 0 0 0 17 9 % S
% Thr: 9 0 0 0 0 0 0 0 0 9 9 0 0 0 17 % T
% Val: 25 9 0 25 0 9 9 0 9 0 0 9 50 0 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 9 17 9 9 17 9 9 42 0 0 9 0 0 9 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _