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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMC8
All Species:
0.91
Human Site:
S658
Identified Species:
2.22
UniProt:
Q8IU68
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IU68
NP_689681.2
726
81641
S658
P
E
P
G
P
S
D
S
P
G
P
K
Y
P
A
Chimpanzee
Pan troglodytes
XP_510854
723
83614
L655
V
S
T
F
P
S
S
L
Q
S
F
I
H
G
V
Rhesus Macaque
Macaca mulatta
XP_001083257
723
83551
L655
V
S
T
F
P
S
S
L
Q
S
F
I
H
G
V
Dog
Lupus familis
XP_540461
714
80565
L647
Q
V
Q
E
K
W
H
L
V
E
D
L
S
R
L
Cat
Felis silvestris
Mouse
Mus musculus
Q7TN58
722
82311
P655
D
D
L
S
R
L
L
P
E
L
S
P
E
P
G
Rat
Rattus norvegicus
Q496Z4
698
78193
S613
G
P
F
Q
G
K
L
S
I
W
A
Q
I
P
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521022
487
53729
P420
E
S
P
F
S
Q
R
P
R
R
G
S
F
C
P
Chicken
Gallus gallus
Q5YCC5
735
84359
A668
A
V
P
F
F
V
I
A
C
L
F
M
F
Y
F
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395471
756
87723
F689
A
G
F
G
V
P
A
F
V
I
L
T
L
F
L
Nematode Worm
Caenorhab. elegans
Q11069
1203
136041
D1126
E
K
G
R
L
I
P
D
R
P
P
I
P
H
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
35.1
35.2
78.3
N.A.
78.3
33.4
N.A.
36.5
34.6
N.A.
N.A.
N.A.
N.A.
28
21.7
N.A.
Protein Similarity:
100
53.5
53.4
84.9
N.A.
84.3
50.1
N.A.
46
53.7
N.A.
N.A.
N.A.
N.A.
46.4
34.3
N.A.
P-Site Identity:
100
13.3
13.3
0
N.A.
6.6
13.3
N.A.
6.6
6.6
N.A.
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
100
20
20
0
N.A.
13.3
20
N.A.
13.3
20
N.A.
N.A.
N.A.
N.A.
6.6
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
0
0
0
0
0
10
10
0
0
10
0
0
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
10
0
0
0
0
10
0
% C
% Asp:
10
10
0
0
0
0
10
10
0
0
10
0
0
0
0
% D
% Glu:
20
10
0
10
0
0
0
0
10
10
0
0
10
0
10
% E
% Phe:
0
0
20
40
10
0
0
10
0
0
30
0
20
10
10
% F
% Gly:
10
10
10
20
10
0
0
0
0
10
10
0
0
20
10
% G
% His:
0
0
0
0
0
0
10
0
0
0
0
0
20
10
0
% H
% Ile:
0
0
0
0
0
10
10
0
10
10
0
30
10
0
0
% I
% Lys:
0
10
0
0
10
10
0
0
0
0
0
10
0
0
0
% K
% Leu:
0
0
10
0
10
10
20
30
0
20
10
10
10
0
20
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
10
10
30
0
30
10
10
20
10
10
20
10
10
30
10
% P
% Gln:
10
0
10
10
0
10
0
0
20
0
0
10
0
0
0
% Q
% Arg:
0
0
0
10
10
0
10
0
20
10
0
0
0
10
0
% R
% Ser:
0
30
0
10
10
30
20
20
0
20
10
10
10
0
10
% S
% Thr:
0
0
20
0
0
0
0
0
0
0
0
10
0
0
0
% T
% Val:
20
20
0
0
10
10
0
0
20
0
0
0
0
0
20
% V
% Trp:
0
0
0
0
0
10
0
0
0
10
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
10
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _