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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMPRSS6
All Species:
11.21
Human Site:
Y50
Identified Species:
27.41
UniProt:
Q8IU80
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IU80
NP_705837.1
811
90000
Y50
S
K
R
K
A
R
G
Y
L
R
L
V
P
L
F
Chimpanzee
Pan troglodytes
XP_516646
843
94354
W71
S
K
K
K
V
P
F
W
N
V
Q
N
K
I
I
Rhesus Macaque
Macaca mulatta
XP_001085319
809
89813
Y50
S
K
R
K
A
R
G
Y
L
R
L
A
P
L
W
Dog
Lupus familis
XP_850550
822
91046
Y41
S
K
R
K
V
R
D
Y
L
R
L
V
P
L
W
Cat
Felis silvestris
Mouse
Mus musculus
Q9DBI0
811
90960
Y54
T
K
R
K
N
R
D
Y
V
R
F
T
P
L
L
Rat
Rattus norvegicus
P86091
833
93268
W57
P
K
K
R
A
P
F
W
N
V
Q
N
K
I
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506444
827
91664
L30
G
P
K
R
W
V
M
L
L
V
V
V
T
G
A
Chicken
Gallus gallus
XP_416281
1098
122755
C336
S
E
T
N
L
R
V
C
L
R
Y
V
S
L
G
Frog
Xenopus laevis
NP_001088059
845
93692
P40
K
K
V
E
K
T
G
P
K
K
K
L
A
I
F
Zebra Danio
Brachydanio rerio
NP_001035441
827
91123
K35
E
K
K
K
G
P
G
K
I
G
I
I
V
G
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
31.9
96.4
91
N.A.
83.5
33.1
N.A.
32.5
51.2
30.2
31.3
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
48.8
98
93.4
N.A.
89.8
49.3
N.A.
50.5
60.6
50
49.9
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
20
86.6
80
N.A.
53.3
13.3
N.A.
13.3
40
20
20
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
40
93.3
86.6
N.A.
66.6
40
N.A.
33.3
46.6
46.6
46.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
30
0
0
0
0
0
0
10
10
0
10
% A
% Cys:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
20
0
0
0
0
0
0
0
0
% D
% Glu:
10
10
0
10
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
20
0
0
0
10
0
0
0
20
% F
% Gly:
10
0
0
0
10
0
40
0
0
10
0
0
0
20
10
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
10
0
10
10
0
30
20
% I
% Lys:
10
80
40
60
10
0
0
10
10
10
10
0
20
0
0
% K
% Leu:
0
0
0
0
10
0
0
10
50
0
30
10
0
50
20
% L
% Met:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
10
10
0
0
0
20
0
0
20
0
0
0
% N
% Pro:
10
10
0
0
0
30
0
10
0
0
0
0
40
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
20
0
0
0
0
% Q
% Arg:
0
0
40
20
0
50
0
0
0
50
0
0
0
0
0
% R
% Ser:
50
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% S
% Thr:
10
0
10
0
0
10
0
0
0
0
0
10
10
0
0
% T
% Val:
0
0
10
0
20
10
10
0
10
30
10
40
10
0
0
% V
% Trp:
0
0
0
0
10
0
0
20
0
0
0
0
0
0
20
% W
% Tyr:
0
0
0
0
0
0
0
40
0
0
10
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _