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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIAH1
All Species:
43.03
Human Site:
T235
Identified Species:
78.89
UniProt:
Q8IUQ4
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IUQ4
NP_001006611.1
282
31123
T235
N
G
H
R
R
R
L
T
W
E
A
T
P
R
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001083570
277
31013
E232
H
R
R
R
L
T
W
E
A
T
P
L
P
I
H
Dog
Lupus familis
XP_544419
313
34552
T266
N
G
H
R
R
R
L
T
W
E
A
T
P
R
S
Cat
Felis silvestris
Mouse
Mus musculus
Q06985
282
31103
T235
N
G
H
R
R
R
L
T
W
E
A
T
P
R
S
Rat
Rattus norvegicus
Q920M9
282
31118
T235
N
G
H
R
R
R
L
T
W
E
A
T
P
R
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507643
433
47638
T386
N
G
H
R
R
R
L
T
W
E
A
T
P
R
S
Chicken
Gallus gallus
Frog
Xenopus laevis
Q9I8X5
313
34081
T264
N
G
N
R
R
R
L
T
W
E
A
T
P
R
S
Zebra Danio
Brachydanio rerio
Q7ZVG6
282
31061
T235
N
G
H
R
R
R
L
T
W
E
A
T
P
R
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P21461
314
33689
T267
N
G
N
R
R
R
L
T
W
E
A
M
P
R
S
Honey Bee
Apis mellifera
XP_394284
279
30558
E234
H
K
R
R
L
T
W
E
A
M
P
R
S
I
H
Nematode Worm
Caenorhab. elegans
Q965X6
339
37641
S287
S
A
S
R
R
R
M
S
W
E
A
T
P
R
S
Sea Urchin
Strong. purpuratus
XP_797311
281
31248
S234
N
G
H
R
R
R
L
S
W
E
A
T
P
R
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P93748
305
34539
T253
G
A
H
S
R
K
L
T
W
Q
G
I
P
R
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
69.8
89.7
N.A.
97.1
99.6
N.A.
64.9
N.A.
71.5
97.5
N.A.
70.3
80.5
58.7
82.2
Protein Similarity:
100
N.A.
80.1
89.7
N.A.
98.9
100
N.A.
64.9
N.A.
79.5
99.6
N.A.
77
89
68.7
87.5
P-Site Identity:
100
N.A.
13.3
100
N.A.
100
100
N.A.
100
N.A.
93.3
100
N.A.
86.6
6.6
66.6
93.3
P-Site Similarity:
100
N.A.
20
100
N.A.
100
100
N.A.
100
N.A.
100
100
N.A.
93.3
13.3
86.6
100
Percent
Protein Identity:
N.A.
N.A.
N.A.
31.8
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
50.8
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
53.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
66.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
16
0
0
0
0
0
0
16
0
77
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
16
0
77
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
70
0
0
0
0
0
0
0
0
8
0
0
0
0
% G
% His:
16
0
62
0
0
0
0
0
0
0
0
0
0
0
16
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
8
0
16
0
% I
% Lys:
0
8
0
0
0
8
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
16
0
77
0
0
0
0
8
0
0
0
% L
% Met:
0
0
0
0
0
0
8
0
0
8
0
8
0
0
0
% M
% Asn:
70
0
16
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
16
0
93
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% Q
% Arg:
0
8
16
93
85
77
0
0
0
0
0
8
0
85
0
% R
% Ser:
8
0
8
8
0
0
0
16
0
0
0
0
8
0
85
% S
% Thr:
0
0
0
0
0
16
0
70
0
8
0
70
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
16
0
85
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _