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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AGXT2L2 All Species: 30.61
Human Site: S22 Identified Species: 44.89
UniProt: Q8IUZ5 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IUZ5 NP_699204.1 450 49711 S22 R Q R L I S S S C R L F F P E
Chimpanzee Pan troglodytes XP_001137764 499 55702 S21 R K K H I G P S C K V F F A S
Rhesus Macaque Macaca mulatta XP_001095786 450 49770 S22 R Q R L I S S S C R L F F P E
Dog Lupus familis XP_538569 450 49862 S22 R R R L L S N S C R L F Y P E
Cat Felis silvestris
Mouse Mus musculus Q8R1K4 467 51947 S22 R R R L L S S S C R L F F P E
Rat Rattus norvegicus Q64565 512 57182 A30 M R P S L S C A S R I Y V P K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518367 451 50169 S22 R R R L I G S S C R L F F S E
Chicken Gallus gallus XP_414688 533 59234 S104 R R Q L I G S S C K L F Y P N
Frog Xenopus laevis Q6DEB1 509 56952 S21 R K K H I G P S C K V F F A N
Zebra Danio Brachydanio rerio Q7SY54 492 54717 S22 R K K H V G P S C K V F F D H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VU95 494 54265 A32 R N Q H I G Q A C Q L F Y R S
Honey Bee Apis mellifera XP_392348 482 53855 A24 R D R Y I G Q A C K L F Y K S
Nematode Worm Caenorhab. elegans P91408 467 51626 K41 R K D T I G S K C Q I F Y S D
Sea Urchin Strong. purpuratus XP_793741 543 60687 P24 I F Y L G R S P C K L W F K E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q940M2 476 51934 P69 K R K K F L G P S L F H Y Y Q
Baker's Yeast Sacchar. cerevisiae P07991 424 46067 H21 W E N K Y S A H N Y H P L P V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 60.1 96.8 87.7 N.A. 83.9 31.8 N.A. 81.3 64.1 56.5 57.1 N.A. 47.3 53.3 44.1 45.6
Protein Similarity: 100 74.9 98.4 94.6 N.A. 89.9 49.6 N.A. 90.9 75 73.4 73.3 N.A. 66.5 72.6 65 62
P-Site Identity: 100 40 100 73.3 N.A. 86.6 20 N.A. 80 60 40 33.3 N.A. 33.3 40 33.3 40
P-Site Similarity: 100 66.6 100 100 N.A. 100 60 N.A. 86.6 86.6 66.6 66.6 N.A. 60 60 66.6 53.3
Percent
Protein Identity: N.A. N.A. N.A. 38.8 26.8 N.A.
Protein Similarity: N.A. N.A. N.A. 56.9 47.7 N.A.
P-Site Identity: N.A. N.A. N.A. 0 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 7 19 0 0 0 0 0 13 0 % A
% Cys: 0 0 0 0 0 0 7 0 82 0 0 0 0 0 0 % C
% Asp: 0 7 7 0 0 0 0 0 0 0 0 0 0 7 7 % D
% Glu: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 38 % E
% Phe: 0 7 0 0 7 0 0 0 0 0 7 75 50 0 0 % F
% Gly: 0 0 0 0 7 50 7 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 25 0 0 0 7 0 0 7 7 0 0 7 % H
% Ile: 7 0 0 0 57 0 0 0 0 0 13 0 0 0 0 % I
% Lys: 7 25 25 13 0 0 0 7 0 38 0 0 0 13 7 % K
% Leu: 0 0 0 44 19 7 0 0 0 7 57 0 7 0 0 % L
% Met: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 7 7 0 0 0 7 0 7 0 0 0 0 0 13 % N
% Pro: 0 0 7 0 0 0 19 13 0 0 0 7 0 44 0 % P
% Gln: 0 13 13 0 0 0 13 0 0 13 0 0 0 0 7 % Q
% Arg: 75 38 38 0 0 7 0 0 0 38 0 0 0 7 0 % R
% Ser: 0 0 0 7 0 38 44 57 13 0 0 0 0 13 19 % S
% Thr: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 7 0 0 0 0 0 19 0 7 0 7 % V
% Trp: 7 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % W
% Tyr: 0 0 7 7 7 0 0 0 0 7 0 7 38 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _