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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLEKHH2
All Species:
17.27
Human Site:
S629
Identified Species:
47.5
UniProt:
Q8IVE3
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IVE3
NP_742066.2
1493
168229
S629
S
G
S
E
E
E
D
S
S
R
S
S
S
R
T
Chimpanzee
Pan troglodytes
XP_525888
1493
168136
S629
S
G
S
E
E
E
D
S
S
R
S
S
S
R
T
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_538474
1531
172747
S667
S
G
S
E
E
E
D
S
S
R
S
S
S
R
T
Cat
Felis silvestris
Mouse
Mus musculus
Q8C115
1491
167731
S628
S
G
S
D
E
E
D
S
S
R
S
S
S
R
L
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516496
937
103987
S142
P
K
T
C
R
S
S
S
D
A
G
K
N
E
P
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q00IB7
1433
160027
S569
G
S
E
D
D
S
S
S
L
A
S
L
H
T
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W5D0
1820
198623
L835
P
S
S
G
Q
L
S
L
P
R
Y
H
A
N
A
Honey Bee
Apis mellifera
XP_001120273
1571
174100
S636
D
S
S
L
G
S
G
S
S
P
S
K
S
V
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782886
2057
229359
N753
K
M
L
A
G
S
S
N
T
L
P
T
A
G
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
N.A.
92.8
N.A.
85.8
N.A.
N.A.
50.4
N.A.
N.A.
52.7
N.A.
31.2
32.9
N.A.
30.7
Protein Similarity:
100
99.5
N.A.
94.9
N.A.
91.5
N.A.
N.A.
56.8
N.A.
N.A.
67.7
N.A.
46
49
N.A.
45
P-Site Identity:
100
100
N.A.
100
N.A.
86.6
N.A.
N.A.
6.6
N.A.
N.A.
13.3
N.A.
13.3
33.3
N.A.
0
P-Site Similarity:
100
100
N.A.
100
N.A.
93.3
N.A.
N.A.
20
N.A.
N.A.
33.3
N.A.
26.6
33.3
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
12
0
0
0
0
0
23
0
0
23
0
12
% A
% Cys:
0
0
0
12
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
12
0
0
23
12
0
45
0
12
0
0
0
0
0
0
% D
% Glu:
0
0
12
34
45
45
0
0
0
0
0
0
0
12
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
12
45
0
12
23
0
12
0
0
0
12
0
0
12
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
12
12
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
12
12
0
0
0
0
0
0
0
0
0
23
0
0
12
% K
% Leu:
0
0
12
12
0
12
0
12
12
12
0
12
0
0
12
% L
% Met:
0
12
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
12
0
0
0
0
12
12
0
% N
% Pro:
23
0
0
0
0
0
0
0
12
12
12
0
0
0
12
% P
% Gln:
0
0
0
0
12
0
0
0
0
0
0
0
0
0
12
% Q
% Arg:
0
0
0
0
12
0
0
0
0
56
0
0
0
45
0
% R
% Ser:
45
34
67
0
0
45
45
78
56
0
67
45
56
0
12
% S
% Thr:
0
0
12
0
0
0
0
0
12
0
0
12
0
12
34
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
12
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
12
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _