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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PLEKHH2 All Species: 13.03
Human Site: S643 Identified Species: 35.83
UniProt: Q8IVE3 Number Species: 8
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IVE3 NP_742066.2 1493 168229 S643 T S E S D S R S R S G P G S P
Chimpanzee Pan troglodytes XP_525888 1493 168136 S643 T S E S D S R S R S G P G S P
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_538474 1531 172747 S681 T S E S D T R S R S G P G S P
Cat Felis silvestris
Mouse Mus musculus Q8C115 1491 167731 S642 L S E S D A R S R S G P S S P
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516496 937 103987 L156 P L E K S G Y L L K M G G R V
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q00IB7 1433 160027 K583 S T L G P D K K G S T P G S P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9W5D0 1820 198623 P849 A L Q P G S L P S P L Q H M R
Honey Bee Apis mellifera XP_001120273 1571 174100 P650 K T T S S L S P A K R S S S G
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_782886 2057 229359 Q767 Q K R G V S T Q S S A S D A D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 N.A. 92.8 N.A. 85.8 N.A. N.A. 50.4 N.A. N.A. 52.7 N.A. 31.2 32.9 N.A. 30.7
Protein Similarity: 100 99.5 N.A. 94.9 N.A. 91.5 N.A. N.A. 56.8 N.A. N.A. 67.7 N.A. 46 49 N.A. 45
P-Site Identity: 100 100 N.A. 93.3 N.A. 80 N.A. N.A. 13.3 N.A. N.A. 33.3 N.A. 6.6 13.3 N.A. 13.3
P-Site Similarity: 100 100 N.A. 100 N.A. 86.6 N.A. N.A. 13.3 N.A. N.A. 53.3 N.A. 13.3 20 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 12 0 0 0 0 12 0 0 12 0 12 0 0 12 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 45 12 0 0 0 0 0 0 12 0 12 % D
% Glu: 0 0 56 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 23 12 12 0 0 12 0 45 12 56 0 12 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 12 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 12 12 0 12 0 0 12 12 0 23 0 0 0 0 0 % K
% Leu: 12 23 12 0 0 12 12 12 12 0 12 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 12 0 0 12 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 12 0 0 12 12 0 0 23 0 12 0 56 0 0 56 % P
% Gln: 12 0 12 0 0 0 0 12 0 0 0 12 0 0 0 % Q
% Arg: 0 0 12 0 0 0 45 0 45 0 12 0 0 12 12 % R
% Ser: 12 45 0 56 23 45 12 45 23 67 0 23 23 67 0 % S
% Thr: 34 23 12 0 0 12 12 0 0 0 12 0 0 0 0 % T
% Val: 0 0 0 0 12 0 0 0 0 0 0 0 0 0 12 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 12 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _