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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLEKHH2
All Species:
14.85
Human Site:
T599
Identified Species:
40.83
UniProt:
Q8IVE3
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IVE3
NP_742066.2
1493
168229
T599
L
I
Y
K
N
M
T
T
P
V
Y
T
T
L
K
Chimpanzee
Pan troglodytes
XP_525888
1493
168136
T599
L
I
Y
K
N
M
T
T
P
V
Y
T
T
L
K
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_538474
1531
172747
T637
L
I
Y
K
N
M
T
T
P
V
Y
T
T
L
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8C115
1491
167731
T598
L
I
Y
K
N
M
T
T
P
V
Y
T
T
L
K
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516496
937
103987
S112
L
S
S
V
T
S
E
S
D
Y
A
I
P
P
D
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q00IB7
1433
160027
P539
I
Y
K
N
I
S
V
P
V
Y
S
T
L
K
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W5D0
1820
198623
S805
I
N
Q
H
L
Q
P
S
Q
H
Q
H
H
T
L
Honey Bee
Apis mellifera
XP_001120273
1571
174100
D606
D
S
S
D
D
S
S
D
G
E
E
H
P
N
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782886
2057
229359
K723
H
G
S
L
K
F
L
K
N
S
K
G
T
G
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
N.A.
92.8
N.A.
85.8
N.A.
N.A.
50.4
N.A.
N.A.
52.7
N.A.
31.2
32.9
N.A.
30.7
Protein Similarity:
100
99.5
N.A.
94.9
N.A.
91.5
N.A.
N.A.
56.8
N.A.
N.A.
67.7
N.A.
46
49
N.A.
45
P-Site Identity:
100
100
N.A.
100
N.A.
100
N.A.
N.A.
6.6
N.A.
N.A.
6.6
N.A.
0
0
N.A.
6.6
P-Site Similarity:
100
100
N.A.
100
N.A.
100
N.A.
N.A.
13.3
N.A.
N.A.
13.3
N.A.
13.3
20
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
12
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
12
0
0
12
12
0
0
12
12
0
0
0
0
0
12
% D
% Glu:
0
0
0
0
0
0
12
0
0
12
12
0
0
0
0
% E
% Phe:
0
0
0
0
0
12
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
12
0
0
0
0
0
0
12
0
0
12
0
12
23
% G
% His:
12
0
0
12
0
0
0
0
0
12
0
23
12
0
0
% H
% Ile:
23
45
0
0
12
0
0
0
0
0
0
12
0
0
0
% I
% Lys:
0
0
12
45
12
0
0
12
0
0
12
0
0
12
45
% K
% Leu:
56
0
0
12
12
0
12
0
0
0
0
0
12
45
12
% L
% Met:
0
0
0
0
0
45
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
12
0
12
45
0
0
0
12
0
0
0
0
12
0
% N
% Pro:
0
0
0
0
0
0
12
12
45
0
0
0
23
12
0
% P
% Gln:
0
0
12
0
0
12
0
0
12
0
12
0
0
0
12
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
23
34
0
0
34
12
23
0
12
12
0
0
0
0
% S
% Thr:
0
0
0
0
12
0
45
45
0
0
0
56
56
12
0
% T
% Val:
0
0
0
12
0
0
12
0
12
45
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
12
45
0
0
0
0
0
0
23
45
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _