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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLEKHH2
All Species:
10
Human Site:
Y514
Identified Species:
27.5
UniProt:
Q8IVE3
Number Species:
8
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IVE3
NP_742066.2
1493
168229
Y514
C
D
D
G
L
F
S
Y
D
S
L
D
S
P
N
Chimpanzee
Pan troglodytes
XP_525888
1493
168136
Y514
C
D
D
G
L
F
S
Y
D
S
L
D
S
P
N
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_538474
1531
172747
Y552
C
D
D
G
L
F
S
Y
D
S
L
E
S
P
C
Cat
Felis silvestris
Mouse
Mus musculus
Q8C115
1491
167731
D513
D
D
G
L
F
S
Y
D
S
Q
D
P
P
P
C
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516496
937
103987
V27
L
L
Y
Y
K
S
P
V
S
S
R
F
C
P
G
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q00IB7
1433
160027
Q454
G
S
E
I
T
E
A
Q
P
N
D
G
D
L
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W5D0
1820
198623
D720
P
F
T
G
D
S
S
D
D
S
S
D
G
E
D
Honey Bee
Apis mellifera
XP_001120273
1571
174100
S521
P
P
L
H
R
F
P
S
W
E
A
K
I
Y
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782886
2057
229359
S638
K
G
L
K
M
S
P
S
V
A
P
V
I
D
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
N.A.
92.8
N.A.
85.8
N.A.
N.A.
50.4
N.A.
N.A.
52.7
N.A.
31.2
32.9
N.A.
30.7
Protein Similarity:
100
99.5
N.A.
94.9
N.A.
91.5
N.A.
N.A.
56.8
N.A.
N.A.
67.7
N.A.
46
49
N.A.
45
P-Site Identity:
100
100
N.A.
86.6
N.A.
13.3
N.A.
N.A.
13.3
N.A.
N.A.
0
N.A.
33.3
6.6
N.A.
0
P-Site Similarity:
100
100
N.A.
93.3
N.A.
13.3
N.A.
N.A.
13.3
N.A.
N.A.
20
N.A.
40
6.6
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
12
0
0
12
12
0
0
0
0
% A
% Cys:
34
0
0
0
0
0
0
0
0
0
0
0
12
0
23
% C
% Asp:
12
45
34
0
12
0
0
23
45
0
23
34
12
12
12
% D
% Glu:
0
0
12
0
0
12
0
0
0
12
0
12
0
12
0
% E
% Phe:
0
12
0
0
12
45
0
0
0
0
0
12
0
0
0
% F
% Gly:
12
12
12
45
0
0
0
0
0
0
0
12
12
0
12
% G
% His:
0
0
0
12
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
12
0
0
0
0
0
0
0
0
23
0
0
% I
% Lys:
12
0
0
12
12
0
0
0
0
0
0
12
0
0
0
% K
% Leu:
12
12
23
12
34
0
0
0
0
0
34
0
0
12
12
% L
% Met:
0
0
0
0
12
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
12
0
0
0
0
23
% N
% Pro:
23
12
0
0
0
0
34
0
12
0
12
12
12
56
0
% P
% Gln:
0
0
0
0
0
0
0
12
0
12
0
0
0
0
12
% Q
% Arg:
0
0
0
0
12
0
0
0
0
0
12
0
0
0
0
% R
% Ser:
0
12
0
0
0
45
45
23
23
56
12
0
34
0
12
% S
% Thr:
0
0
12
0
12
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
12
12
0
0
12
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
12
0
0
0
0
0
0
% W
% Tyr:
0
0
12
12
0
0
12
34
0
0
0
0
0
12
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _