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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDKL3 All Species: 20.91
Human Site: S551 Identified Species: 35.38
UniProt: Q8IVW4 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IVW4 NP_001107047.1 592 67514 S551 I K M L K R E S K K T E S S K
Chimpanzee Pan troglodytes XP_517934 592 67566 S551 I K M L K R E S K K T E S S K
Rhesus Macaque Macaca mulatta XP_001108660 592 67612 S551 I K M L K R E S K K T D S S K
Dog Lupus familis XP_850612 456 51739 S439 P P I N L T S S N L M A S N P
Cat Felis silvestris
Mouse Mus musculus Q8BLF2 595 67720 S553 I K V L K R E S K K T D S S K
Rat Rattus norvegicus Q9JM01 593 67534 S553 I K V L K R E S K K T D S P K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512927 637 71445 V552 W T G G G M R V R Q T P Y P L
Chicken Gallus gallus P13863 303 34670 Y286 K M A L N H P Y F D D L D K S
Frog Xenopus laevis P35567 302 34487 P285 A R K A L L H P Y F D D L D K
Zebra Danio Brachydanio rerio Q6AXJ9 350 40792 N333 T V F P A V E N R R N Y N N L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P23572 297 34420 D280 V H R I S A K D I L E H P Y F
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784044 926 104004 A570 H T T M P Q I A N Q S D H G G
Poplar Tree Populus trichocarpa
Maize Zea mays P23111 294 33816 T277 Y E P S K R I T A R Q A L E H
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P24100 294 34012 N277 M D P T K R I N A R A A L E H
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 98.9 67.7 N.A. 80.5 79 N.A. 57.7 25 24.3 31 N.A. 23.4 N.A. N.A. 30.2
Protein Similarity: 100 99.8 99.6 72.1 N.A. 89.7 87.6 N.A. 68.9 34.9 35.6 43 N.A. 35.1 N.A. N.A. 44
P-Site Identity: 100 100 93.3 13.3 N.A. 86.6 80 N.A. 6.6 6.6 6.6 6.6 N.A. 0 N.A. N.A. 0
P-Site Similarity: 100 100 100 26.6 N.A. 100 93.3 N.A. 20 6.6 20 40 N.A. 20 N.A. N.A. 40
Percent
Protein Identity: N.A. 22.8 N.A. 23.1 N.A. N.A.
Protein Similarity: N.A. 33.9 N.A. 33.9 N.A. N.A.
P-Site Identity: N.A. 13.3 N.A. 13.3 N.A. N.A.
P-Site Similarity: N.A. 33.3 N.A. 33.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 8 8 8 8 0 8 15 0 8 22 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 0 0 0 0 0 8 0 8 15 36 8 8 0 % D
% Glu: 0 8 0 0 0 0 43 0 0 0 8 15 0 15 0 % E
% Phe: 0 0 8 0 0 0 0 0 8 8 0 0 0 0 8 % F
% Gly: 0 0 8 8 8 0 0 0 0 0 0 0 0 8 8 % G
% His: 8 8 0 0 0 8 8 0 0 0 0 8 8 0 15 % H
% Ile: 36 0 8 8 0 0 22 0 8 0 0 0 0 0 0 % I
% Lys: 8 36 8 0 50 0 8 0 36 36 0 0 0 8 43 % K
% Leu: 0 0 0 43 15 8 0 0 0 15 0 8 22 0 15 % L
% Met: 8 8 22 8 0 8 0 0 0 0 8 0 0 0 0 % M
% Asn: 0 0 0 8 8 0 0 15 15 0 8 0 8 15 0 % N
% Pro: 8 8 15 8 8 0 8 8 0 0 0 8 8 15 8 % P
% Gln: 0 0 0 0 0 8 0 0 0 15 8 0 0 0 0 % Q
% Arg: 0 8 8 0 0 50 8 0 15 22 0 0 0 0 0 % R
% Ser: 0 0 0 8 8 0 8 43 0 0 8 0 43 29 8 % S
% Thr: 8 15 8 8 0 8 0 8 0 0 43 0 0 0 0 % T
% Val: 8 8 15 0 0 8 0 8 0 0 0 0 0 0 0 % V
% Trp: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 0 8 8 0 0 8 8 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _