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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDKL3 All Species: 16.67
Human Site: T331 Identified Species: 28.21
UniProt: Q8IVW4 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IVW4 NP_001107047.1 592 67514 T331 L R K D E R K T V Y T N T L L
Chimpanzee Pan troglodytes XP_517934 592 67566 T331 L R K D E R K T V Y T N T L L
Rhesus Macaque Macaca mulatta XP_001108660 592 67612 T331 L R K D E R K T V Y T N T L L
Dog Lupus familis XP_850612 456 51739 G236 S T S P I F A G V V L P Q V Q
Cat Felis silvestris
Mouse Mus musculus Q8BLF2 595 67720 S331 P V R D E K K S V F T N T L L
Rat Rattus norvegicus Q9JM01 593 67534 P331 P V R D E K K P V F T N P L L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512927 637 71445 A331 P I K E E R K A V H V N K I A
Chicken Gallus gallus P13863 303 34670 L83 L Y L I F E F L S M D L K K Y
Frog Xenopus laevis P35567 302 34487 F82 R L Y L I F E F L S M D L K K
Zebra Danio Brachydanio rerio Q6AXJ9 350 40792 E130 I H R D V K P E N I L I T K H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P23572 297 34420 Y77 L M E E N R I Y L I F E F L S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784044 926 104004 T388 V K K S N P S T V T E S Q K K
Poplar Tree Populus trichocarpa
Maize Zea mays P23111 294 33816 K74 H D V V H S E K R I Y L V F E
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P24100 294 34012 K74 Q D V V H S E K R L Y L V F E
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 98.9 67.7 N.A. 80.5 79 N.A. 57.7 25 24.3 31 N.A. 23.4 N.A. N.A. 30.2
Protein Similarity: 100 99.8 99.6 72.1 N.A. 89.7 87.6 N.A. 68.9 34.9 35.6 43 N.A. 35.1 N.A. N.A. 44
P-Site Identity: 100 100 100 6.6 N.A. 60 53.3 N.A. 40 6.6 0 13.3 N.A. 20 N.A. N.A. 20
P-Site Similarity: 100 100 100 13.3 N.A. 86.6 73.3 N.A. 60 6.6 20 33.3 N.A. 40 N.A. N.A. 40
Percent
Protein Identity: N.A. 22.8 N.A. 23.1 N.A. N.A.
Protein Similarity: N.A. 33.9 N.A. 33.9 N.A. N.A.
P-Site Identity: N.A. 0 N.A. 0 N.A. N.A.
P-Site Similarity: N.A. 6.6 N.A. 6.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 8 8 0 0 0 0 0 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 15 0 43 0 0 0 0 0 0 8 8 0 0 0 % D
% Glu: 0 0 8 15 43 8 22 8 0 0 8 8 0 0 15 % E
% Phe: 0 0 0 0 8 15 8 8 0 15 8 0 8 15 0 % F
% Gly: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % G
% His: 8 8 0 0 15 0 0 0 0 8 0 0 0 0 8 % H
% Ile: 8 8 0 8 15 0 8 0 0 22 0 8 0 8 0 % I
% Lys: 0 8 36 0 0 22 43 15 0 0 0 0 15 29 15 % K
% Leu: 36 8 8 8 0 0 0 8 15 8 15 22 8 43 36 % L
% Met: 0 8 0 0 0 0 0 0 0 8 8 0 0 0 0 % M
% Asn: 0 0 0 0 15 0 0 0 8 0 0 43 0 0 0 % N
% Pro: 22 0 0 8 0 8 8 8 0 0 0 8 8 0 0 % P
% Gln: 8 0 0 0 0 0 0 0 0 0 0 0 15 0 8 % Q
% Arg: 8 22 22 0 0 36 0 0 15 0 0 0 0 0 0 % R
% Ser: 8 0 8 8 0 15 8 8 8 8 0 8 0 0 8 % S
% Thr: 0 8 0 0 0 0 0 29 0 8 36 0 36 0 0 % T
% Val: 8 15 15 15 8 0 0 0 58 8 8 0 15 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 8 0 0 0 0 8 0 22 15 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _