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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CARKD All Species: 26.67
Human Site: S267 Identified Species: 45.13
UniProt: Q8IW45 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IW45 NP_060680.2 347 36576 S267 V C S Q E G S S R R C G G Q G
Chimpanzee Pan troglodytes XP_001138081 347 36596 S267 V C S Q E G S S R R C G G Q G
Rhesus Macaque Macaca mulatta XP_001083130 347 36777 S267 V C S Q E G S S R R C G G Q G
Dog Lupus familis XP_849113 379 40113 S299 E C T Q E G S S R R C G G Q G
Cat Felis silvestris
Mouse Mus musculus Q9CZ42 343 36699 S263 V C N Q E G S S R R C G G Q G
Rat Rattus norvegicus NP_001101872 327 34944 S247 V C N Q E G S S R R C G G Q G
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_416954 626 69229 S546 V C S H E G S S R R C G G Q G
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001103590 424 46535 G344 T C S Q E G S G R R C G G Q G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623353 329 36035 G231 S C G L A G S G R R C G G Q G
Nematode Worm Caenorhab. elegans P32740 307 33871 A227 G G Q G D V T A G S L G L F L
Sea Urchin Strong. purpuratus XP_791028 343 37314 P254 V C C G E G S P R R C G G Q G
Poplar Tree Populus trichocarpa XP_002312747 368 40017 P282 S V S N H G S P R R C G G Q G
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_568369 365 39251 P283 S V S I Y G S P R R C G G Q G
Baker's Yeast Sacchar. cerevisiae P36059 337 37339 N242 T N S E E G S N K R V G G Q G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.5 93.6 70.7 N.A. 80.1 75.7 N.A. N.A. 42.8 N.A. 52.3 N.A. N.A. 41.7 36.5 48.9
Protein Similarity: 100 99.1 95 80.2 N.A. 88.1 85.5 N.A. N.A. 50.7 N.A. 64.8 N.A. N.A. 59.3 51.8 68
P-Site Identity: 100 100 100 86.6 N.A. 93.3 93.3 N.A. N.A. 93.3 N.A. 86.6 N.A. N.A. 66.6 6.6 80
P-Site Similarity: 100 100 100 93.3 N.A. 100 100 N.A. N.A. 93.3 N.A. 86.6 N.A. N.A. 66.6 26.6 80
Percent
Protein Identity: 41.3 N.A. N.A. 41.3 38.9 N.A.
Protein Similarity: 59.7 N.A. N.A. 58 59 N.A.
P-Site Identity: 66.6 N.A. N.A. 66.6 60 N.A.
P-Site Similarity: 66.6 N.A. N.A. 66.6 80 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 8 0 0 8 0 0 0 0 0 0 0 % A
% Cys: 0 72 8 0 0 0 0 0 0 0 86 0 0 0 0 % C
% Asp: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 8 0 0 8 72 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % F
% Gly: 8 8 8 15 0 93 0 15 8 0 0 100 93 0 93 % G
% His: 0 0 0 8 8 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % K
% Leu: 0 0 0 8 0 0 0 0 0 0 8 0 8 0 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 8 15 8 0 0 0 8 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 22 0 0 0 0 0 0 0 % P
% Gln: 0 0 8 50 0 0 0 0 0 0 0 0 0 93 0 % Q
% Arg: 0 0 0 0 0 0 0 0 86 93 0 0 0 0 0 % R
% Ser: 22 0 58 0 0 0 93 50 0 8 0 0 0 0 0 % S
% Thr: 15 0 8 0 0 0 8 0 0 0 0 0 0 0 0 % T
% Val: 50 15 0 0 0 8 0 0 0 0 8 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _