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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CARKD All Species: 43.03
Human Site: T242 Identified Species: 72.82
UniProt: Q8IW45 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IW45 NP_060680.2 347 36576 T242 S Q A L G N V T V V Q K G E R
Chimpanzee Pan troglodytes XP_001138081 347 36596 T242 S Q A L G N V T V V Q K G E R
Rhesus Macaque Macaca mulatta XP_001083130 347 36777 T242 S Q A L G N V T V V Q K G E R
Dog Lupus familis XP_849113 379 40113 T274 S Q A L G N V T V V Q K G E R
Cat Felis silvestris
Mouse Mus musculus Q9CZ42 343 36699 T238 S Q A L G N I T V V Q K G E Q
Rat Rattus norvegicus NP_001101872 327 34944 T222 S Q A L G N I T I V Q K G E Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_416954 626 69229 T521 S Q A L G N L T V V Q K G E R
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001103590 424 46535 T319 S I A L G H L T L V L K G E E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623353 329 36035 H206 G K N V I V L H K G A K D V I
Nematode Worm Caenorhab. elegans P32740 307 33871 T202 G E V D L V V T P N G E V S K
Sea Urchin Strong. purpuratus XP_791028 343 37314 T229 S R S L G H V T V C M K G A N
Poplar Tree Populus trichocarpa XP_002312747 368 40017 T257 A K Q I G E V T I L R K G K C
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_568369 365 39251 T258 A K Q I G G V T I L R K G K S
Baker's Yeast Sacchar. cerevisiae P36059 337 37339 E217 E L N C I V V E K G Q S D K I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.5 93.6 70.7 N.A. 80.1 75.7 N.A. N.A. 42.8 N.A. 52.3 N.A. N.A. 41.7 36.5 48.9
Protein Similarity: 100 99.1 95 80.2 N.A. 88.1 85.5 N.A. N.A. 50.7 N.A. 64.8 N.A. N.A. 59.3 51.8 68
P-Site Identity: 100 100 100 100 N.A. 86.6 80 N.A. N.A. 93.3 N.A. 60 N.A. N.A. 6.6 13.3 53.3
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. N.A. 100 N.A. 80 N.A. N.A. 26.6 33.3 73.3
Percent
Protein Identity: 41.3 N.A. N.A. 41.3 38.9 N.A.
Protein Similarity: 59.7 N.A. N.A. 58 59 N.A.
P-Site Identity: 33.3 N.A. N.A. 33.3 13.3 N.A.
P-Site Similarity: 80 N.A. N.A. 80 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 15 0 58 0 0 0 0 0 0 0 8 0 0 8 0 % A
% Cys: 0 0 0 8 0 0 0 0 0 8 0 0 0 0 8 % C
% Asp: 0 0 0 8 0 0 0 0 0 0 0 0 15 0 0 % D
% Glu: 8 8 0 0 0 8 0 8 0 0 0 8 0 58 8 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 15 0 0 0 79 8 0 0 0 15 8 0 79 0 0 % G
% His: 0 0 0 0 0 15 0 8 0 0 0 0 0 0 0 % H
% Ile: 0 8 0 15 15 0 15 0 22 0 0 0 0 0 15 % I
% Lys: 0 22 0 0 0 0 0 0 15 0 0 86 0 22 8 % K
% Leu: 0 8 0 65 8 0 22 0 8 15 8 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % M
% Asn: 0 0 15 0 0 50 0 0 0 8 0 0 0 0 8 % N
% Pro: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % P
% Gln: 0 50 15 0 0 0 0 0 0 0 58 0 0 0 15 % Q
% Arg: 0 8 0 0 0 0 0 0 0 0 15 0 0 0 36 % R
% Ser: 65 0 8 0 0 0 0 0 0 0 0 8 0 8 8 % S
% Thr: 0 0 0 0 0 0 0 86 0 0 0 0 0 0 0 % T
% Val: 0 0 8 8 0 22 65 0 50 58 0 0 8 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _