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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CARKD All Species: 32.73
Human Site: T328 Identified Species: 55.38
UniProt: Q8IW45 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IW45 NP_060680.2 347 36576 T328 F Q K H G R S T T T S D M I A
Chimpanzee Pan troglodytes XP_001138081 347 36596 T328 F Q K H G R S T T T S D M I A
Rhesus Macaque Macaca mulatta XP_001083130 347 36777 T328 F Q K H G R S T T T S D M I A
Dog Lupus familis XP_849113 379 40113 T360 F Q K H G R S T T T T D M I A
Cat Felis silvestris
Mouse Mus musculus Q9CZ42 343 36699 T324 F Q K Y G R S T T T T D M I T
Rat Rattus norvegicus NP_001101872 327 34944 T308 F Q K Y G R S T T T T D M I A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_416954 626 69229 M607 F Q K L G R S M T A S D M V S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001103590 424 46535 T405 F H K H G R S T T T S D M I Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623353 329 36035 M291 Y K L K Q R G M L T T D I L E
Nematode Worm Caenorhab. elegans P32740 307 33871 R289 D E I P K L V R D V E T R E M
Sea Urchin Strong. purpuratus XP_791028 343 37314 M322 F E K N G R G M T T T E M L P
Poplar Tree Populus trichocarpa XP_002312747 368 40017 T348 F E D R K R S T L T T D I I E
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_568369 365 39251 T345 F T K H K R S T L T S D I I E
Baker's Yeast Sacchar. cerevisiae P36059 337 37339 M319 F K A K G R A M Q T T D L N D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.5 93.6 70.7 N.A. 80.1 75.7 N.A. N.A. 42.8 N.A. 52.3 N.A. N.A. 41.7 36.5 48.9
Protein Similarity: 100 99.1 95 80.2 N.A. 88.1 85.5 N.A. N.A. 50.7 N.A. 64.8 N.A. N.A. 59.3 51.8 68
P-Site Identity: 100 100 100 93.3 N.A. 80 86.6 N.A. N.A. 66.6 N.A. 86.6 N.A. N.A. 20 0 46.6
P-Site Similarity: 100 100 100 100 N.A. 93.3 100 N.A. N.A. 80 N.A. 86.6 N.A. N.A. 53.3 6.6 80
Percent
Protein Identity: 41.3 N.A. N.A. 41.3 38.9 N.A.
Protein Similarity: 59.7 N.A. N.A. 58 59 N.A.
P-Site Identity: 46.6 N.A. N.A. 66.6 33.3 N.A.
P-Site Similarity: 66.6 N.A. N.A. 73.3 60 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 0 0 0 8 0 0 8 0 0 0 0 36 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 8 0 0 0 0 0 8 0 0 86 0 0 8 % D
% Glu: 0 22 0 0 0 0 0 0 0 0 8 8 0 8 22 % E
% Phe: 86 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 72 0 15 0 0 0 0 0 0 0 0 % G
% His: 0 8 0 43 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 8 0 0 0 0 0 0 0 0 0 22 65 0 % I
% Lys: 0 15 72 15 22 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 8 8 0 8 0 0 22 0 0 0 8 15 0 % L
% Met: 0 0 0 0 0 0 0 29 0 0 0 0 65 0 8 % M
% Asn: 0 0 0 8 0 0 0 0 0 0 0 0 0 8 0 % N
% Pro: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 8 % P
% Gln: 0 50 0 0 8 0 0 0 8 0 0 0 0 0 8 % Q
% Arg: 0 0 0 8 0 93 0 8 0 0 0 0 8 0 0 % R
% Ser: 0 0 0 0 0 0 72 0 0 0 43 0 0 0 8 % S
% Thr: 0 8 0 0 0 0 0 65 65 86 50 8 0 0 8 % T
% Val: 0 0 0 0 0 0 8 0 0 8 0 0 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 15 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _