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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ARHGEF19
All Species:
1.21
Human Site:
T226
Identified Species:
2.96
UniProt:
Q8IW93
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IW93
NP_694945.2
802
89197
T226
A
L
I
S
G
S
G
T
G
A
A
R
E
G
K
Chimpanzee
Pan troglodytes
XP_524519
638
70607
S136
S
H
G
S
E
K
K
S
A
W
R
K
M
R
V
Rhesus Macaque
Macaca mulatta
XP_001092728
1124
123968
G411
P
W
T
V
L
A
A
G
R
S
S
L
A
E
P
Dog
Lupus familis
XP_544545
644
72189
R143
K
S
A
W
R
K
M
R
V
Y
Q
R
E
E
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8BWA8
802
88833
A224
V
L
T
S
G
S
G
A
G
A
I
R
E
G
K
Rat
Rattus norvegicus
Q5BKC9
701
80989
G200
E
I
Q
G
N
S
D
G
S
Q
A
G
E
D
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518094
555
62698
G54
E
E
T
G
G
S
P
G
S
E
D
H
A
A
F
Chicken
Gallus gallus
XP_417225
1733
193947
W1162
R
R
V
K
S
K
D
W
H
R
Q
G
L
K
R
Frog
Xenopus laevis
NP_001128552
856
97785
H284
A
G
V
A
T
L
L
H
P
G
M
E
S
D
S
Zebra Danio
Brachydanio rerio
XP_697662
977
110044
R389
S
D
Y
K
P
N
S
R
H
R
F
S
G
G
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
78.9
42.5
72.6
N.A.
84.4
32.2
N.A.
43
25.4
52.3
45.1
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
79
49.4
75.1
N.A.
88
50.1
N.A.
49.8
34
64.3
56.5
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
0
13.3
N.A.
73.3
20
N.A.
13.3
0
6.6
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
26.6
20
13.3
N.A.
73.3
26.6
N.A.
13.3
13.3
20
20
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
0
10
10
0
10
10
10
10
20
20
0
20
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
0
0
0
20
0
0
0
10
0
0
20
0
% D
% Glu:
20
10
0
0
10
0
0
0
0
10
0
10
40
20
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
10
% F
% Gly:
0
10
10
20
30
0
20
30
20
10
0
20
10
30
0
% G
% His:
0
10
0
0
0
0
0
10
20
0
0
10
0
0
0
% H
% Ile:
0
10
10
0
0
0
0
0
0
0
10
0
0
0
0
% I
% Lys:
10
0
0
20
0
30
10
0
0
0
0
10
0
10
20
% K
% Leu:
0
20
0
0
10
10
10
0
0
0
0
10
10
0
10
% L
% Met:
0
0
0
0
0
0
10
0
0
0
10
0
10
0
0
% M
% Asn:
0
0
0
0
10
10
0
0
0
0
0
0
0
0
10
% N
% Pro:
10
0
0
0
10
0
10
0
10
0
0
0
0
0
10
% P
% Gln:
0
0
10
0
0
0
0
0
0
10
20
0
0
0
0
% Q
% Arg:
10
10
0
0
10
0
0
20
10
20
10
30
0
10
10
% R
% Ser:
20
10
0
30
10
40
10
10
20
10
10
10
10
0
20
% S
% Thr:
0
0
30
0
10
0
0
10
0
0
0
0
0
0
0
% T
% Val:
10
0
20
10
0
0
0
0
10
0
0
0
0
0
10
% V
% Trp:
0
10
0
10
0
0
0
10
0
10
0
0
0
0
0
% W
% Tyr:
0
0
10
0
0
0
0
0
0
10
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _