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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
WDR75
All Species:
23.64
Human Site:
S642
Identified Species:
40
UniProt:
Q8IWA0
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IWA0
NP_115544.1
830
94499
S642
V
P
R
D
V
P
E
S
F
T
S
E
A
Y
Q
Chimpanzee
Pan troglodytes
XP_001164827
830
94495
S642
V
P
R
D
V
P
E
S
F
T
S
E
A
Y
Q
Rhesus Macaque
Macaca mulatta
XP_001106363
830
94421
S642
V
P
R
D
V
P
E
S
F
T
S
E
A
Y
Q
Dog
Lupus familis
XP_545565
829
94501
S642
V
P
R
D
V
P
E
S
F
T
S
E
A
Y
Q
Cat
Felis silvestris
Mouse
Mus musculus
NP_082875
830
94018
S641
V
P
R
D
V
P
E
S
F
T
S
E
T
H
Q
Rat
Rattus norvegicus
NP_001041354
649
74096
S464
D
V
P
E
S
F
T
S
E
A
H
Q
W
L
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520401
496
54144
Q312
S
Q
W
L
N
R
S
Q
F
Y
F
L
T
E
N
Chicken
Gallus gallus
XP_001233408
833
93957
T646
V
P
R
D
V
P
E
T
I
G
S
E
K
Y
L
Frog
Xenopus laevis
Q6DFC6
832
94031
F645
V
P
K
E
I
P
E
F
V
K
S
E
S
H
Q
Zebra Danio
Brachydanio rerio
Q7ZVR1
832
93918
N640
V
P
R
E
E
P
F
N
S
C
D
E
S
C
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_610086
1071
119989
R799
I
W
N
L
L
T
L
R
L
Q
A
G
L
K
L
Honey Bee
Apis mellifera
XP_623200
807
90558
S623
H
L
R
E
K
R
D
S
S
Y
K
I
W
Q
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_798367
969
106463
G768
G
D
G
N
D
K
E
G
L
S
N
D
A
L
P
Poplar Tree
Populus trichocarpa
XP_002329663
812
88693
I627
Y
M
L
H
V
E
A
I
A
S
A
A
D
M
S
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.6
90.7
N.A.
84.9
64.2
N.A.
31.5
61.8
60.8
53.8
N.A.
24.2
26.1
N.A.
29.4
Protein Similarity:
100
100
99.4
95.3
N.A.
92.4
70.4
N.A.
40.9
77.1
76.6
70.6
N.A.
40
45.2
N.A.
46.7
P-Site Identity:
100
100
100
100
N.A.
86.6
6.6
N.A.
6.6
66.6
46.6
40
N.A.
0
13.3
N.A.
13.3
P-Site Similarity:
100
100
100
100
N.A.
93.3
20
N.A.
6.6
73.3
80
60
N.A.
20
33.3
N.A.
40
Percent
Protein Identity:
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
44.1
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
20
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
8
0
8
8
15
8
36
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
8
0
0
0
8
0
% C
% Asp:
8
8
0
43
8
0
8
0
0
0
8
8
8
0
0
% D
% Glu:
0
0
0
29
8
8
58
0
8
0
0
58
0
8
0
% E
% Phe:
0
0
0
0
0
8
8
8
43
0
8
0
0
0
0
% F
% Gly:
8
0
8
0
0
0
0
8
0
8
0
8
0
0
0
% G
% His:
8
0
0
8
0
0
0
0
0
0
8
0
0
15
0
% H
% Ile:
8
0
0
0
8
0
0
8
8
0
0
8
0
0
0
% I
% Lys:
0
0
8
0
8
8
0
0
0
8
8
0
8
8
0
% K
% Leu:
0
8
8
15
8
0
8
0
15
0
0
8
8
15
15
% L
% Met:
0
8
0
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
8
8
8
0
0
8
0
0
8
0
0
0
15
% N
% Pro:
0
58
8
0
0
58
0
0
0
0
0
0
0
0
8
% P
% Gln:
0
8
0
0
0
0
0
8
0
8
0
8
0
8
50
% Q
% Arg:
0
0
58
0
0
15
0
8
0
0
0
0
0
0
8
% R
% Ser:
8
0
0
0
8
0
8
50
15
15
50
0
15
0
8
% S
% Thr:
0
0
0
0
0
8
8
8
0
36
0
0
15
0
0
% T
% Val:
58
8
0
0
50
0
0
0
8
0
0
0
0
0
0
% V
% Trp:
0
8
8
0
0
0
0
0
0
0
0
0
15
0
0
% W
% Tyr:
8
0
0
0
0
0
0
0
0
15
0
0
0
36
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _