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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
WDR75
All Species:
20.91
Human Site:
Y619
Identified Species:
35.38
UniProt:
Q8IWA0
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IWA0
NP_115544.1
830
94499
Y619
P
S
E
P
R
P
L
Y
I
Q
K
G
I
S
R
Chimpanzee
Pan troglodytes
XP_001164827
830
94495
Y619
P
S
E
P
R
P
L
Y
I
Q
K
G
I
S
R
Rhesus Macaque
Macaca mulatta
XP_001106363
830
94421
Y619
P
S
E
P
R
P
L
Y
I
Q
K
G
I
S
R
Dog
Lupus familis
XP_545565
829
94501
Y619
P
S
E
P
R
P
L
Y
I
Q
K
N
I
S
R
Cat
Felis silvestris
Mouse
Mus musculus
NP_082875
830
94018
Y618
P
S
E
P
R
P
L
Y
I
Q
K
N
V
S
R
Rat
Rattus norvegicus
NP_001041354
649
74096
V443
P
L
Y
I
Q
K
N
V
S
R
E
K
V
Q
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520401
496
54144
F291
E
K
V
L
Y
A
V
F
V
S
R
D
V
P
E
Chicken
Gallus gallus
XP_001233408
833
93957
C623
P
N
E
A
R
P
I
C
I
Q
R
K
F
C
K
Frog
Xenopus laevis
Q6DFC6
832
94031
Y622
P
S
E
P
R
P
F
Y
T
Q
K
N
I
C
Q
Zebra Danio
Brachydanio rerio
Q7ZVR1
832
93918
F617
P
S
E
P
R
P
L
F
S
Q
R
Y
V
C
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_610086
1071
119989
K736
S
S
K
P
K
K
E
K
T
G
K
C
K
L
N
Honey Bee
Apis mellifera
XP_623200
807
90558
I602
I
Y
T
K
K
N
V
I
E
N
N
S
S
I
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_798367
969
106463
F739
G
C
E
P
R
P
V
F
Y
Q
P
S
T
S
S
Poplar Tree
Populus trichocarpa
XP_002329663
812
88693
L606
S
W
G
S
K
P
Q
L
S
I
W
S
M
S
K
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.6
90.7
N.A.
84.9
64.2
N.A.
31.5
61.8
60.8
53.8
N.A.
24.2
26.1
N.A.
29.4
Protein Similarity:
100
100
99.4
95.3
N.A.
92.4
70.4
N.A.
40.9
77.1
76.6
70.6
N.A.
40
45.2
N.A.
46.7
P-Site Identity:
100
100
100
93.3
N.A.
86.6
6.6
N.A.
0
40
66.6
53.3
N.A.
20
0
N.A.
40
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
33.3
N.A.
33.3
66.6
73.3
73.3
N.A.
33.3
13.3
N.A.
53.3
Percent
Protein Identity:
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
44.1
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
33.3
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
8
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
8
0
0
0
0
0
8
0
0
0
8
0
22
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% D
% Glu:
8
0
65
0
0
0
8
0
8
0
8
0
0
0
8
% E
% Phe:
0
0
0
0
0
0
8
22
0
0
0
0
8
0
0
% F
% Gly:
8
0
8
0
0
0
0
0
0
8
0
22
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
8
0
0
8
8
43
8
0
0
36
8
0
% I
% Lys:
0
8
8
8
22
15
0
8
0
0
50
15
8
0
15
% K
% Leu:
0
8
0
8
0
0
43
8
0
0
0
0
0
8
15
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% M
% Asn:
0
8
0
0
0
8
8
0
0
8
8
22
0
0
8
% N
% Pro:
65
0
0
65
0
72
0
0
0
0
8
0
0
8
0
% P
% Gln:
0
0
0
0
8
0
8
0
0
65
0
0
0
8
8
% Q
% Arg:
0
0
0
0
65
0
0
0
0
8
22
0
0
0
36
% R
% Ser:
15
58
0
8
0
0
0
0
22
8
0
22
8
50
8
% S
% Thr:
0
0
8
0
0
0
0
0
15
0
0
0
8
0
0
% T
% Val:
0
0
8
0
0
0
22
8
8
0
0
0
29
0
0
% V
% Trp:
0
8
0
0
0
0
0
0
0
0
8
0
0
0
8
% W
% Tyr:
0
8
8
0
8
0
0
43
8
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _