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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLEKHM2
All Species:
22.73
Human Site:
Y170
Identified Species:
71.43
UniProt:
Q8IWE5
Number Species:
7
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IWE5
NP_055979.2
1019
112780
Y170
A
P
Y
M
P
D
Y
Y
K
P
Q
Y
L
L
D
Chimpanzee
Pan troglodytes
XP_513054
1187
130336
Y338
A
P
Y
M
P
D
Y
Y
K
P
Q
Y
L
L
D
Rhesus Macaque
Macaca mulatta
XP_001089676
1047
115576
Y198
A
P
Y
M
P
D
Y
Y
K
P
Q
Y
L
L
D
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q80TQ5
1018
112715
Y170
A
P
Y
M
P
D
Y
Y
K
P
Q
Y
L
L
D
Rat
Rattus norvegicus
XP_233611
1031
114174
Y170
A
P
Y
M
P
D
Y
Y
K
P
Q
Y
L
L
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509787
1008
111006
Y169
A
P
Y
M
P
D
Y
Y
K
P
Q
Y
L
L
D
Chicken
Gallus gallus
XP_417616
1140
125251
R299
V
S
G
L
E
F
I
R
F
D
L
D
L
D
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_397241
1109
125896
P173
C
N
Y
M
P
Q
R
P
M
S
V
N
P
S
G
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.3
95.5
N.A.
N.A.
87
87.9
N.A.
81
67
N.A.
N.A.
N.A.
N.A.
20.9
N.A.
N.A.
Protein Similarity:
100
85.3
96.1
N.A.
N.A.
91.3
92.3
N.A.
87.4
73.7
N.A.
N.A.
N.A.
N.A.
38.7
N.A.
N.A.
P-Site Identity:
100
100
100
N.A.
N.A.
100
100
N.A.
100
6.6
N.A.
N.A.
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
100
100
100
N.A.
N.A.
100
100
N.A.
100
13.3
N.A.
N.A.
N.A.
N.A.
20
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
75
0
0
0
0
0
0
0
0
0
0
0
0
0
13
% A
% Cys:
13
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
75
0
0
0
13
0
13
0
13
75
% D
% Glu:
0
0
0
0
13
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
13
0
0
13
0
0
0
0
0
0
% F
% Gly:
0
0
13
0
0
0
0
0
0
0
0
0
0
0
13
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
13
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
75
0
0
0
0
0
0
% K
% Leu:
0
0
0
13
0
0
0
0
0
0
13
0
88
75
0
% L
% Met:
0
0
0
88
0
0
0
0
13
0
0
0
0
0
0
% M
% Asn:
0
13
0
0
0
0
0
0
0
0
0
13
0
0
0
% N
% Pro:
0
75
0
0
88
0
0
13
0
75
0
0
13
0
0
% P
% Gln:
0
0
0
0
0
13
0
0
0
0
75
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
13
13
0
0
0
0
0
0
0
% R
% Ser:
0
13
0
0
0
0
0
0
0
13
0
0
0
13
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
13
0
0
0
0
0
0
0
0
0
13
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
88
0
0
0
75
75
0
0
0
75
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _