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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
LRRC8A
All Species:
31.21
Human Site:
S748
Identified Species:
76.3
UniProt:
Q8IWT6
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IWT6
NP_001120716.1
810
94199
S748
N
V
L
Q
S
L
P
S
R
V
G
E
L
T
N
Chimpanzee
Pan troglodytes
XP_001160980
841
97525
S779
N
V
L
Q
S
L
P
S
R
V
G
E
L
T
N
Rhesus Macaque
Macaca mulatta
XP_001109419
754
87489
N712
G
L
L
Q
N
L
Q
N
L
A
I
T
A
N
R
Dog
Lupus familis
XP_548430
810
94076
S748
N
V
L
Q
S
L
P
S
R
V
G
E
L
T
N
Cat
Felis silvestris
Mouse
Mus musculus
Q80WG5
810
94101
S748
N
V
L
Q
S
L
P
S
R
V
G
E
L
T
N
Rat
Rattus norvegicus
Q4V8I7
810
94143
S748
N
V
L
Q
S
L
P
S
R
V
G
E
L
T
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514421
809
93645
S747
N
V
L
Q
S
L
P
S
R
V
G
E
L
T
N
Chicken
Gallus gallus
XP_415484
810
94346
S748
N
V
L
Q
S
L
P
S
R
V
G
E
L
T
N
Frog
Xenopus laevis
Q6NU09
806
92226
P749
N
R
L
A
S
L
S
P
K
V
G
S
L
V
C
Zebra Danio
Brachydanio rerio
XP_686175
796
93027
S734
N
C
L
Q
S
L
P
S
R
F
G
E
L
T
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95
90.1
98.8
N.A.
99
98.6
N.A.
93.4
94.9
55.1
85.4
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
95.4
90.8
99.3
N.A.
99.3
99.1
N.A.
97.5
97.5
71.1
91.8
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
20
100
N.A.
100
100
N.A.
100
100
46.6
80
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
40
100
N.A.
100
100
N.A.
100
100
53.3
86.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
0
0
0
0
0
10
0
0
10
0
0
% A
% Cys:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
10
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
80
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% F
% Gly:
10
0
0
0
0
0
0
0
0
0
90
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% K
% Leu:
0
10
100
0
0
100
0
0
10
0
0
0
90
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
90
0
0
0
10
0
0
10
0
0
0
0
0
10
70
% N
% Pro:
0
0
0
0
0
0
80
10
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
90
0
0
10
0
0
0
0
0
0
0
0
% Q
% Arg:
0
10
0
0
0
0
0
0
80
0
0
0
0
0
10
% R
% Ser:
0
0
0
0
90
0
10
80
0
0
0
10
0
0
10
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
10
0
80
0
% T
% Val:
0
70
0
0
0
0
0
0
0
80
0
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _