KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TPH2
All Species:
26.97
Human Site:
S104
Identified Species:
42.38
UniProt:
Q8IWU9
Number Species:
14
Phosphosite Substitution
Charge Score:
0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IWU9
NP_775489.2
490
56057
S104
R
K
S
R
R
R
S
S
E
V
E
I
F
V
D
Chimpanzee
Pan troglodytes
XP_522470
490
55999
S104
R
K
S
R
R
R
S
S
E
V
E
I
F
V
D
Rhesus Macaque
Macaca mulatta
Q2HZ26
490
56076
S104
R
K
S
R
R
R
S
S
E
V
E
I
F
V
D
Dog
Lupus familis
XP_538286
708
77776
S321
R
K
S
R
R
R
S
S
E
V
E
I
F
V
D
Cat
Felis silvestris
Mouse
Mus musculus
Q8CGV2
488
55899
S102
R
R
S
R
R
R
S
S
E
V
E
I
F
V
D
Rat
Rattus norvegicus
Q8CGU9
485
55603
S99
R
R
S
R
R
R
S
S
E
V
E
I
F
V
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519524
444
50785
C65
E
F
E
I
F
V
D
C
D
T
N
R
E
Q
L
Chicken
Gallus gallus
P70080
445
51121
C66
E
F
E
I
F
V
D
C
D
S
N
R
E
Q
L
Frog
Xenopus laevis
Q92142
481
55388
S95
R
K
S
K
R
R
N
S
E
F
E
I
F
V
D
Zebra Danio
Brachydanio rerio
NP_999960
473
54279
E91
C
T
K
K
E
F
N
E
L
V
Q
H
L
K
D
Tiger Blowfish
Takifugu rubipres
NP_001027849
486
55494
D100
R
A
S
R
R
L
T
D
E
V
E
I
F
A
D
Fruit Fly
Dros. melanogaster
P17276
452
51642
V73
E
S
R
S
S
L
R
V
P
G
Y
E
F
F
V
Honey Bee
Apis mellifera
XP_394674
508
57954
V95
E
Y
E
I
L
V
D
V
E
C
D
S
K
R
M
Nematode Worm
Caenorhab. elegans
P90925
457
52111
F78
C
Y
E
V
L
V
E
F
A
E
A
E
D
H
R
Sea Urchin
Strong. purpuratus
XP_784134
479
54807
E94
L
E
I
F
V
D
C
E
G
K
K
K
M
L
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.7
58.9
N.A.
93
93.6
N.A.
68.3
68.5
68.7
72.2
80
48.5
56.6
46.7
53.2
Protein Similarity:
100
99.5
99.1
63.7
N.A.
95.3
96.7
N.A.
79.8
80.8
83.2
83
88.5
66.1
70.8
65.5
69.5
P-Site Identity:
100
100
100
100
N.A.
93.3
93.3
N.A.
0
0
80
13.3
66.6
6.6
6.6
0
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
6.6
6.6
93.3
33.3
73.3
6.6
13.3
0
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
0
0
0
0
7
0
7
0
0
7
0
% A
% Cys:
14
0
0
0
0
0
7
14
0
7
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
7
20
7
14
0
7
0
7
0
60
% D
% Glu:
27
7
27
0
7
0
7
14
60
7
54
14
14
0
0
% E
% Phe:
0
14
0
7
14
7
0
7
0
7
0
0
60
7
0
% F
% Gly:
0
0
0
0
0
0
0
0
7
7
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
7
0
7
0
% H
% Ile:
0
0
7
20
0
0
0
0
0
0
0
54
0
0
0
% I
% Lys:
0
34
7
14
0
0
0
0
0
7
7
7
7
7
7
% K
% Leu:
7
0
0
0
14
14
0
0
7
0
0
0
7
7
14
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
7
% M
% Asn:
0
0
0
0
0
0
14
0
0
0
14
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
7
0
0
14
0
% Q
% Arg:
54
14
7
47
54
47
7
0
0
0
0
14
0
7
7
% R
% Ser:
0
7
54
7
7
0
40
47
0
7
0
7
0
0
0
% S
% Thr:
0
7
0
0
0
0
7
0
0
7
0
0
0
0
0
% T
% Val:
0
0
0
7
7
27
0
14
0
54
0
0
0
47
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
14
0
0
0
0
0
0
0
0
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _