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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TPH2
All Species:
35.45
Human Site:
S159
Identified Species:
55.71
UniProt:
Q8IWU9
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IWU9
NP_775489.2
490
56057
S159
P
W
F
P
R
K
I
S
E
L
D
K
C
S
H
Chimpanzee
Pan troglodytes
XP_522470
490
55999
S159
P
W
F
P
R
K
I
S
E
L
D
K
C
S
H
Rhesus Macaque
Macaca mulatta
Q2HZ26
490
56076
S159
P
W
F
P
R
K
I
S
E
L
D
K
C
S
H
Dog
Lupus familis
XP_538286
708
77776
S376
P
W
F
P
R
K
I
S
E
L
D
R
C
S
H
Cat
Felis silvestris
Mouse
Mus musculus
Q8CGV2
488
55899
S157
P
W
F
P
R
K
I
S
E
L
D
R
C
S
H
Rat
Rattus norvegicus
Q8CGU9
485
55603
S154
P
W
F
P
R
K
I
S
E
L
D
R
C
S
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519524
444
50785
A119
I
S
D
L
D
K
C
A
N
R
V
L
M
Y
G
Chicken
Gallus gallus
P70080
445
51121
A120
I
S
D
L
D
K
C
A
N
R
V
L
M
Y
G
Frog
Xenopus laevis
Q92142
481
55388
S150
P
W
F
P
K
K
I
S
D
L
D
K
C
A
N
Zebra Danio
Brachydanio rerio
NP_999960
473
54279
D145
P
Q
K
I
S
E
L
D
Q
C
S
H
R
V
L
Tiger Blowfish
Takifugu rubipres
NP_001027849
486
55494
S155
P
W
F
P
M
K
I
S
E
L
D
Q
C
S
H
Fruit Fly
Dros. melanogaster
P17276
452
51642
L127
F
P
R
R
I
R
D
L
D
R
F
A
N
Q
I
Honey Bee
Apis mellifera
XP_394674
508
57954
I153
M
P
W
F
P
R
K
I
S
D
L
D
Q
A
Q
Nematode Worm
Caenorhab. elegans
P90925
457
52111
A132
I
N
D
I
D
Q
F
A
N
R
I
L
S
Y
G
Sea Urchin
Strong. purpuratus
XP_784134
479
54807
S148
P
D
F
P
R
K
I
S
E
L
D
Q
S
A
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.7
58.9
N.A.
93
93.6
N.A.
68.3
68.5
68.7
72.2
80
48.5
56.6
46.7
53.2
Protein Similarity:
100
99.5
99.1
63.7
N.A.
95.3
96.7
N.A.
79.8
80.8
83.2
83
88.5
66.1
70.8
65.5
69.5
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
6.6
6.6
73.3
6.6
86.6
0
0
0
66.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
13.3
13.3
100
26.6
93.3
13.3
20
13.3
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
20
0
0
0
7
0
20
0
% A
% Cys:
0
0
0
0
0
0
14
0
0
7
0
0
54
0
0
% C
% Asp:
0
7
20
0
20
0
7
7
14
7
60
7
0
0
0
% D
% Glu:
0
0
0
0
0
7
0
0
54
0
0
0
0
0
0
% E
% Phe:
7
0
60
7
0
0
7
0
0
0
7
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
20
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
47
% H
% Ile:
20
0
0
14
7
0
60
7
0
0
7
0
0
0
7
% I
% Lys:
0
0
7
0
7
74
7
0
0
0
0
27
0
0
0
% K
% Leu:
0
0
0
14
0
0
7
7
0
60
7
20
0
0
7
% L
% Met:
7
0
0
0
7
0
0
0
0
0
0
0
14
0
0
% M
% Asn:
0
7
0
0
0
0
0
0
20
0
0
0
7
0
14
% N
% Pro:
67
14
0
60
7
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
7
0
0
0
7
0
0
7
0
0
14
7
7
7
% Q
% Arg:
0
0
7
7
47
14
0
0
0
27
0
20
7
0
0
% R
% Ser:
0
14
0
0
7
0
0
60
7
0
7
0
14
47
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
14
0
0
7
0
% V
% Trp:
0
54
7
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
20
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _