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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TPH2
All Species:
23.64
Human Site:
S228
Identified Species:
37.14
UniProt:
Q8IWU9
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IWU9
NP_775489.2
490
56057
S228
G
V
V
F
R
E
L
S
K
L
Y
P
T
H
A
Chimpanzee
Pan troglodytes
XP_522470
490
55999
S228
G
V
V
F
R
E
L
S
K
L
Y
P
T
H
A
Rhesus Macaque
Macaca mulatta
Q2HZ26
490
56076
S228
G
V
V
F
R
E
L
S
K
L
Y
P
T
H
A
Dog
Lupus familis
XP_538286
708
77776
C445
G
V
V
F
R
E
L
C
K
L
Y
P
T
H
A
Cat
Felis silvestris
Mouse
Mus musculus
Q8CGV2
488
55899
S226
G
V
V
F
R
E
L
S
K
L
Y
P
T
H
A
Rat
Rattus norvegicus
Q8CGU9
485
55603
S223
G
V
V
F
R
E
L
S
K
L
Y
P
T
H
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519524
444
50785
H188
L
N
K
L
Y
P
T
H
A
C
R
E
Y
L
K
Chicken
Gallus gallus
P70080
445
51121
H189
L
N
K
L
Y
P
T
H
A
C
R
E
Y
L
K
Frog
Xenopus laevis
Q92142
481
55388
N219
G
T
V
F
R
E
L
N
K
L
Y
P
T
H
A
Zebra Danio
Brachydanio rerio
NP_999960
473
54279
Y214
Y
R
E
L
T
K
L
Y
P
T
H
A
C
R
E
Tiger Blowfish
Takifugu rubipres
NP_001027849
486
55494
T224
G
V
V
F
R
E
L
T
K
L
Y
P
T
H
A
Fruit Fly
Dros. melanogaster
P17276
452
51642
L196
I
F
R
N
L
T
K
L
Y
K
T
H
A
C
R
Honey Bee
Apis mellifera
XP_394674
508
57954
H222
G
T
V
F
R
E
L
H
H
L
Y
Q
K
H
A
Nematode Worm
Caenorhab. elegans
P90925
457
52111
N201
L
T
V
M
Y
P
K
N
A
C
Q
E
F
N
Y
Sea Urchin
Strong. purpuratus
XP_784134
479
54807
N217
G
Q
V
F
S
E
L
N
R
L
Y
P
T
H
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.7
58.9
N.A.
93
93.6
N.A.
68.3
68.5
68.7
72.2
80
48.5
56.6
46.7
53.2
Protein Similarity:
100
99.5
99.1
63.7
N.A.
95.3
96.7
N.A.
79.8
80.8
83.2
83
88.5
66.1
70.8
65.5
69.5
P-Site Identity:
100
100
100
93.3
N.A.
100
100
N.A.
0
0
86.6
6.6
93.3
0
66.6
6.6
73.3
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
0
0
93.3
20
100
0
66.6
20
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
20
0
0
7
7
0
67
% A
% Cys:
0
0
0
0
0
0
0
7
0
20
0
0
7
7
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
7
0
0
67
0
0
0
0
0
20
0
0
7
% E
% Phe:
0
7
0
67
0
0
0
0
0
0
0
0
7
0
0
% F
% Gly:
67
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
20
7
0
7
7
0
67
0
% H
% Ile:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
14
0
0
7
14
0
54
7
0
0
7
0
14
% K
% Leu:
20
0
0
20
7
0
74
7
0
67
0
0
0
14
0
% L
% Met:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
14
0
7
0
0
0
20
0
0
0
0
0
7
0
% N
% Pro:
0
0
0
0
0
20
0
0
7
0
0
60
0
0
0
% P
% Gln:
0
7
0
0
0
0
0
0
0
0
7
7
0
0
0
% Q
% Arg:
0
7
7
0
60
0
0
0
7
0
14
0
0
7
7
% R
% Ser:
0
0
0
0
7
0
0
34
0
0
0
0
0
0
0
% S
% Thr:
0
20
0
0
7
7
14
7
0
7
7
0
60
0
0
% T
% Val:
0
47
74
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
0
20
0
0
7
7
0
67
0
14
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _