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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TPH2
All Species:
35.15
Human Site:
S264
Identified Species:
55.24
UniProt:
Q8IWU9
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IWU9
NP_775489.2
490
56057
S264
V
P
Q
L
E
D
V
S
M
F
L
K
E
R
S
Chimpanzee
Pan troglodytes
XP_522470
490
55999
S264
V
P
Q
L
E
D
V
S
M
F
L
K
E
R
S
Rhesus Macaque
Macaca mulatta
Q2HZ26
490
56076
S264
V
P
Q
L
E
D
V
S
M
F
L
K
E
R
S
Dog
Lupus familis
XP_538286
708
77776
S481
V
P
Q
L
Q
D
V
S
A
F
L
R
E
R
A
Cat
Felis silvestris
Mouse
Mus musculus
Q8CGV2
488
55899
S262
V
P
Q
L
E
D
V
S
M
F
L
K
E
R
S
Rat
Rattus norvegicus
Q8CGU9
485
55603
S259
V
P
Q
L
E
D
V
S
M
F
L
K
E
R
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519524
444
50785
R224
V
S
R
F
L
K
E
R
T
G
F
S
I
R
P
Chicken
Gallus gallus
P70080
445
51121
R225
V
S
R
F
L
K
E
R
T
G
F
T
I
R
P
Frog
Xenopus laevis
Q92142
481
55388
S255
I
P
Q
L
E
D
V
S
R
F
L
R
E
R
T
Zebra Danio
Brachydanio rerio
NP_999960
473
54279
L250
L
E
D
V
S
L
F
L
R
E
R
S
G
F
T
Tiger Blowfish
Takifugu rubipres
NP_001027849
486
55494
S260
V
P
Q
L
E
D
V
S
L
F
L
R
E
R
S
Fruit Fly
Dros. melanogaster
P17276
452
51642
F232
Q
L
E
D
V
S
N
F
L
R
D
C
T
G
F
Honey Bee
Apis mellifera
XP_394674
508
57954
N258
I
P
Q
L
Q
D
V
N
V
F
L
K
R
T
T
Nematode Worm
Caenorhab. elegans
P90925
457
52111
C237
V
S
D
F
L
K
D
C
T
G
Y
T
I
R
P
Sea Urchin
Strong. purpuratus
XP_784134
479
54807
S253
I
P
Q
L
E
D
V
S
R
F
L
K
D
C
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.7
58.9
N.A.
93
93.6
N.A.
68.3
68.5
68.7
72.2
80
48.5
56.6
46.7
53.2
Protein Similarity:
100
99.5
99.1
63.7
N.A.
95.3
96.7
N.A.
79.8
80.8
83.2
83
88.5
66.1
70.8
65.5
69.5
P-Site Identity:
100
100
100
73.3
N.A.
100
100
N.A.
13.3
13.3
73.3
0
86.6
0
53.3
13.3
66.6
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
20
20
93.3
20
100
13.3
86.6
13.3
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
7
% A
% Cys:
0
0
0
0
0
0
0
7
0
0
0
7
0
7
0
% C
% Asp:
0
0
14
7
0
67
7
0
0
0
7
0
7
0
0
% D
% Glu:
0
7
7
0
54
0
14
0
0
7
0
0
54
0
0
% E
% Phe:
0
0
0
20
0
0
7
7
0
67
14
0
0
7
7
% F
% Gly:
0
0
0
0
0
0
0
0
0
20
0
0
7
7
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
20
0
0
0
0
0
0
0
0
0
0
0
20
0
0
% I
% Lys:
0
0
0
0
0
20
0
0
0
0
0
47
0
0
0
% K
% Leu:
7
7
0
67
20
7
0
7
14
0
67
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
34
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
7
7
0
0
0
0
0
0
0
% N
% Pro:
0
67
0
0
0
0
0
0
0
0
0
0
0
0
20
% P
% Gln:
7
0
67
0
14
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
14
0
0
0
0
14
20
7
7
20
7
74
0
% R
% Ser:
0
20
0
0
7
7
0
60
0
0
0
14
0
0
40
% S
% Thr:
0
0
0
0
0
0
0
0
20
0
0
14
7
7
27
% T
% Val:
67
0
0
7
7
0
67
0
7
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _