KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TPH2
All Species:
38.48
Human Site:
Y231
Identified Species:
60.48
UniProt:
Q8IWU9
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IWU9
NP_775489.2
490
56057
Y231
F
R
E
L
S
K
L
Y
P
T
H
A
C
R
E
Chimpanzee
Pan troglodytes
XP_522470
490
55999
Y231
F
R
E
L
S
K
L
Y
P
T
H
A
C
R
E
Rhesus Macaque
Macaca mulatta
Q2HZ26
490
56076
Y231
F
R
E
L
S
K
L
Y
P
T
H
A
C
R
E
Dog
Lupus familis
XP_538286
708
77776
Y448
F
R
E
L
C
K
L
Y
P
T
H
A
C
R
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8CGV2
488
55899
Y229
F
R
E
L
S
K
L
Y
P
T
H
A
C
R
E
Rat
Rattus norvegicus
Q8CGU9
485
55603
Y226
F
R
E
L
S
K
L
Y
P
T
H
A
C
R
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519524
444
50785
R191
L
Y
P
T
H
A
C
R
E
Y
L
K
N
L
P
Chicken
Gallus gallus
P70080
445
51121
R192
L
Y
P
T
H
A
C
R
E
Y
L
K
N
L
P
Frog
Xenopus laevis
Q92142
481
55388
Y222
F
R
E
L
N
K
L
Y
P
T
H
A
C
R
E
Zebra Danio
Brachydanio rerio
NP_999960
473
54279
H217
L
T
K
L
Y
P
T
H
A
C
R
E
Y
L
K
Tiger Blowfish
Takifugu rubipres
NP_001027849
486
55494
Y227
F
R
E
L
T
K
L
Y
P
T
H
A
C
R
E
Fruit Fly
Dros. melanogaster
P17276
452
51642
T199
N
L
T
K
L
Y
K
T
H
A
C
R
E
Y
N
Honey Bee
Apis mellifera
XP_394674
508
57954
Y225
F
R
E
L
H
H
L
Y
Q
K
H
A
C
N
E
Nematode Worm
Caenorhab. elegans
P90925
457
52111
Q204
M
Y
P
K
N
A
C
Q
E
F
N
Y
I
F
P
Sea Urchin
Strong. purpuratus
XP_784134
479
54807
Y220
F
S
E
L
N
R
L
Y
P
T
H
A
C
E
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.7
58.9
N.A.
93
93.6
N.A.
68.3
68.5
68.7
72.2
80
48.5
56.6
46.7
53.2
Protein Similarity:
100
99.5
99.1
63.7
N.A.
95.3
96.7
N.A.
79.8
80.8
83.2
83
88.5
66.1
70.8
65.5
69.5
P-Site Identity:
100
100
100
93.3
N.A.
100
100
N.A.
0
0
93.3
6.6
93.3
0
66.6
0
73.3
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
0
0
100
26.6
100
0
66.6
13.3
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
20
0
0
7
7
0
67
0
0
0
% A
% Cys:
0
0
0
0
7
0
20
0
0
7
7
0
67
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
67
0
0
0
0
0
20
0
0
7
7
7
67
% E
% Phe:
67
0
0
0
0
0
0
0
0
7
0
0
0
7
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
20
7
0
7
7
0
67
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% I
% Lys:
0
0
7
14
0
54
7
0
0
7
0
14
0
0
7
% K
% Leu:
20
7
0
74
7
0
67
0
0
0
14
0
0
20
0
% L
% Met:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
0
0
0
20
0
0
0
0
0
7
0
14
7
7
% N
% Pro:
0
0
20
0
0
7
0
0
60
0
0
0
0
0
20
% P
% Gln:
0
0
0
0
0
0
0
7
7
0
0
0
0
0
0
% Q
% Arg:
0
60
0
0
0
7
0
14
0
0
7
7
0
54
0
% R
% Ser:
0
7
0
0
34
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
7
7
14
7
0
7
7
0
60
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
20
0
0
7
7
0
67
0
14
0
7
7
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _