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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ARHGAP12
All Species:
18.79
Human Site:
S220
Identified Species:
41.33
UniProt:
Q8IWW6
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IWW6
NP_060757.4
846
96254
S220
S
E
S
G
D
E
L
S
S
S
S
T
E
Q
I
Chimpanzee
Pan troglodytes
XP_001139980
845
96085
S218
S
E
S
G
D
E
L
S
S
S
S
T
E
Q
I
Rhesus Macaque
Macaca mulatta
XP_001084325
847
96284
S220
S
E
S
G
D
E
L
S
S
S
S
T
E
Q
I
Dog
Lupus familis
XP_544216
843
95813
S217
S
E
S
G
D
E
L
S
S
S
S
T
E
Q
I
Cat
Felis silvestris
Mouse
Mus musculus
Q8C0D4
838
95334
S218
S
E
S
G
D
E
L
S
S
S
S
T
E
Q
M
Rat
Rattus norvegicus
Q6TLK4
869
97161
S238
E
R
Q
P
Q
V
T
S
P
R
S
A
A
A
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507592
830
94276
P220
S
S
T
E
Q
I
R
P
T
T
P
P
N
Q
G
Chicken
Gallus gallus
Q5ZMM3
475
54591
Frog
Xenopus laevis
NP_001080790
776
87632
E200
L
D
S
E
S
G
D
E
L
S
S
S
S
T
E
Zebra Danio
Brachydanio rerio
NP_957168
817
92412
L220
D
S
E
S
G
D
E
L
S
S
S
S
T
E
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P46941
837
94178
D217
P
L
P
I
P
F
S
D
S
F
T
D
D
E
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.1
98.5
95
N.A.
90.7
35.6
N.A.
85.4
28.6
65.8
62.5
N.A.
N.A.
N.A.
22.7
N.A.
Protein Similarity:
100
98.8
99.4
97.2
N.A.
94.6
50.8
N.A.
91.2
41.1
76.3
74.9
N.A.
N.A.
N.A.
42
N.A.
P-Site Identity:
100
100
100
100
N.A.
93.3
13.3
N.A.
13.3
0
20
20
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
13.3
N.A.
33.3
0
33.3
40
N.A.
N.A.
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
10
10
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
10
0
0
46
10
10
10
0
0
0
10
10
0
10
% D
% Glu:
10
46
10
19
0
46
10
10
0
0
0
0
46
19
10
% E
% Phe:
0
0
0
0
0
10
0
0
0
10
0
0
0
0
0
% F
% Gly:
0
0
0
46
10
10
0
0
0
0
0
0
0
0
10
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% H
% Ile:
0
0
0
10
0
10
0
0
0
0
0
0
0
0
37
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
10
10
0
0
0
0
46
10
10
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% N
% Pro:
10
0
10
10
10
0
0
10
10
0
10
10
0
0
10
% P
% Gln:
0
0
10
0
19
0
0
0
0
0
0
0
0
55
0
% Q
% Arg:
0
10
0
0
0
0
10
0
0
10
0
0
0
0
0
% R
% Ser:
55
19
55
10
10
0
10
55
64
64
73
19
10
0
0
% S
% Thr:
0
0
10
0
0
0
10
0
10
10
10
46
10
10
0
% T
% Val:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _