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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ARHGAP12 All Species: 16.67
Human Site: T457 Identified Species: 36.67
UniProt: Q8IWW6 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IWW6 NP_060757.4 846 96254 T457 S S P K H Q D T A S S P K D Q
Chimpanzee Pan troglodytes XP_001139980 845 96085 T455 S S P K H Q D T A S S P K T K
Rhesus Macaque Macaca mulatta XP_001084325 847 96284 T457 S S P K H Q D T A S S P K D Q
Dog Lupus familis XP_544216 843 95813 T454 S S P K H Q D T A N S P K G Q
Cat Felis silvestris
Mouse Mus musculus Q8C0D4 838 95334 G455 S S K H Q D P G Q E K Y G L L
Rat Rattus norvegicus Q6TLK4 869 97161 I475 A S P P E E K I K T L D K A G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507592 830 94276 T457 K F G V L N V T K I T E N G K
Chicken Gallus gallus Q5ZMM3 475 54591 C137 K P G Y K P E C V D L C G A H
Frog Xenopus laevis NP_001080790 776 87632 S437 A A G W K F G S N Q S K P E F
Zebra Danio Brachydanio rerio NP_957168 817 92412 A457 K K V R K N W A S T W T V L Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P46941 837 94178 S454 V W D L R G A S V T W Y Q D N
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.1 98.5 95 N.A. 90.7 35.6 N.A. 85.4 28.6 65.8 62.5 N.A. N.A. N.A. 22.7 N.A.
Protein Similarity: 100 98.8 99.4 97.2 N.A. 94.6 50.8 N.A. 91.2 41.1 76.3 74.9 N.A. N.A. N.A. 42 N.A.
P-Site Identity: 100 86.6 100 86.6 N.A. 13.3 20 N.A. 6.6 0 6.6 6.6 N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: 100 93.3 100 93.3 N.A. 13.3 40 N.A. 20 6.6 33.3 26.6 N.A. N.A. N.A. 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 19 10 0 0 0 0 10 10 37 0 0 0 0 19 0 % A
% Cys: 0 0 0 0 0 0 0 10 0 0 0 10 0 0 0 % C
% Asp: 0 0 10 0 0 10 37 0 0 10 0 10 0 28 0 % D
% Glu: 0 0 0 0 10 10 10 0 0 10 0 10 0 10 0 % E
% Phe: 0 10 0 0 0 10 0 0 0 0 0 0 0 0 10 % F
% Gly: 0 0 28 0 0 10 10 10 0 0 0 0 19 19 10 % G
% His: 0 0 0 10 37 0 0 0 0 0 0 0 0 0 10 % H
% Ile: 0 0 0 0 0 0 0 10 0 10 0 0 0 0 0 % I
% Lys: 28 10 10 37 28 0 10 0 19 0 10 10 46 0 19 % K
% Leu: 0 0 0 10 10 0 0 0 0 0 19 0 0 19 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 19 0 0 10 10 0 0 10 0 10 % N
% Pro: 0 10 46 10 0 10 10 0 0 0 0 37 10 0 0 % P
% Gln: 0 0 0 0 10 37 0 0 10 10 0 0 10 0 37 % Q
% Arg: 0 0 0 10 10 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 46 55 0 0 0 0 0 19 10 28 46 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 46 0 28 10 10 0 10 0 % T
% Val: 10 0 10 10 0 0 10 0 19 0 0 0 10 0 0 % V
% Trp: 0 10 0 10 0 0 10 0 0 0 19 0 0 0 0 % W
% Tyr: 0 0 0 10 0 0 0 0 0 0 0 19 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _