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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ADHFE1
All Species:
30.61
Human Site:
Y256
Identified Species:
51.79
UniProt:
Q8IWW8
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.23
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IWW8
NP_653251.2
467
50308
Y256
E
S
Y
T
T
L
P
Y
H
L
R
S
P
C
P
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001094680
467
50184
Y256
E
S
Y
T
A
L
P
Y
H
L
R
S
P
C
P
Dog
Lupus familis
XP_849448
419
45266
R221
C
P
S
N
P
I
T
R
P
A
Y
Q
G
S
N
Cat
Felis silvestris
Mouse
Mus musculus
Q8R0N6
465
49919
Y254
E
S
Y
T
A
I
P
Y
S
M
R
S
P
C
P
Rat
Rattus norvegicus
Q4QQW3
467
50207
Y256
E
S
Y
T
A
I
P
Y
S
M
R
S
P
C
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511833
542
59240
Y331
E
S
Y
T
A
L
P
Y
H
M
R
S
P
C
P
Chicken
Gallus gallus
XP_424090
419
45207
R221
C
P
S
N
P
I
N
R
P
A
Y
Q
G
S
N
Frog
Xenopus laevis
Q08B39
463
50154
Y252
E
S
Y
T
A
L
P
Y
N
M
R
S
P
C
P
Zebra Danio
Brachydanio rerio
NP_996969
471
50630
Y260
E
S
F
T
A
L
P
Y
N
L
R
S
P
C
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W265
464
49999
Y253
E
S
F
T
A
V
D
Y
R
E
R
G
L
A
P
Honey Bee
Apis mellifera
XP_624450
418
45967
R220
C
P
S
N
P
N
L
R
P
A
Y
Q
G
S
N
Nematode Worm
Caenorhab. elegans
Q9U2M4
465
50487
F253
E
S
F
T
A
L
P
F
D
Q
R
S
P
R
P
Sea Urchin
Strong. purpuratus
XP_780928
479
51618
Y268
E
S
Y
T
A
I
P
Y
N
E
R
K
P
R
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P10127
382
41124
L184
D
P
S
T
M
F
G
L
P
P
A
L
T
A
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
97.4
83.3
N.A.
89.2
89.7
N.A.
74.7
75.1
79.2
71.5
N.A.
58.4
55.4
47.5
62.2
Protein Similarity:
100
N.A.
98.2
85.8
N.A.
94
94.2
N.A.
81.9
83.3
88.8
84.2
N.A.
75.5
69.5
63.1
76.8
P-Site Identity:
100
N.A.
93.3
0
N.A.
73.3
73.3
N.A.
86.6
0
80
80
N.A.
40
0
60
60
P-Site Similarity:
100
N.A.
93.3
6.6
N.A.
86.6
86.6
N.A.
93.3
6.6
93.3
93.3
N.A.
53.3
0
73.3
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
22
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
40.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
65
0
0
0
0
22
8
0
0
15
8
% A
% Cys:
22
0
0
0
0
0
0
0
0
0
0
0
0
50
0
% C
% Asp:
8
0
0
0
0
0
8
0
8
0
0
0
0
0
0
% D
% Glu:
72
0
0
0
0
0
0
0
0
15
0
0
0
0
0
% E
% Phe:
0
0
22
0
0
8
0
8
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
8
0
0
0
0
8
22
0
0
% G
% His:
0
0
0
0
0
0
0
0
22
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
36
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% K
% Leu:
0
0
0
0
0
43
8
8
0
22
0
8
8
0
0
% L
% Met:
0
0
0
0
8
0
0
0
0
29
0
0
0
0
0
% M
% Asn:
0
0
0
22
0
8
8
0
22
0
0
0
0
0
22
% N
% Pro:
0
29
0
0
22
0
65
0
29
8
0
0
65
0
72
% P
% Gln:
0
0
0
0
0
0
0
0
0
8
0
22
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
22
8
0
72
0
0
15
0
% R
% Ser:
0
72
29
0
0
0
0
0
15
0
0
58
0
22
0
% S
% Thr:
0
0
0
79
8
0
8
0
0
0
0
0
8
0
0
% T
% Val:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
50
0
0
0
0
65
0
0
22
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _