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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ADHFE1 All Species: 33.64
Human Site: Y348 Identified Species: 56.92
UniProt: Q8IWW8 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IWW8 NP_653251.2 467 50308 Y348 K M Y K A K D Y N V D H P L V
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001094680 467 50184 Y348 K T Y K A K D Y N V D H P L V
Dog Lupus familis XP_849448 419 45266 H309 V D H P L V P H G L S V V L T
Cat Felis silvestris
Mouse Mus musculus Q8R0N6 465 49919 Y346 K T Y K A K E Y N V D H P L V
Rat Rattus norvegicus Q4QQW3 467 50207 Y348 K T Y K A K E Y N V D H P L V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511833 542 59240 Y423 K T Y K A K D Y N V D H S L V
Chicken Gallus gallus XP_424090 419 45207 H309 V D H S L V P H G L S V V L T
Frog Xenopus laevis Q08B39 463 50154 Y344 K T Y R A K D Y K V D H P L V
Zebra Danio Brachydanio rerio NP_996969 471 50630 Y352 K T H R A K G Y N V E H P I V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9W265 464 49999 Y345 R D Y K P K G Y S A D H A L I
Honey Bee Apis mellifera XP_624450 418 45967 H308 K G R T I V P H G L S V V I T
Nematode Worm Caenorhab. elegans Q9U2M4 465 50487 Y345 K S C V A D D Y P K E K N L I
Sea Urchin Strong. purpuratus XP_780928 479 51618 Y360 K E Y K S R D Y D V D H A I V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P10127 382 41124 G272 A L A H Q L G G F Y H L P H G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 97.4 83.3 N.A. 89.2 89.7 N.A. 74.7 75.1 79.2 71.5 N.A. 58.4 55.4 47.5 62.2
Protein Similarity: 100 N.A. 98.2 85.8 N.A. 94 94.2 N.A. 81.9 83.3 88.8 84.2 N.A. 75.5 69.5 63.1 76.8
P-Site Identity: 100 N.A. 93.3 6.6 N.A. 86.6 86.6 N.A. 86.6 6.6 80 60 N.A. 46.6 6.6 33.3 60
P-Site Similarity: 100 N.A. 93.3 26.6 N.A. 93.3 93.3 N.A. 86.6 26.6 86.6 86.6 N.A. 66.6 26.6 46.6 86.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 22 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 40.4 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 8 0 58 0 0 0 0 8 0 0 15 0 0 % A
% Cys: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 22 0 0 0 8 43 0 8 0 58 0 0 0 0 % D
% Glu: 0 8 0 0 0 0 15 0 0 0 15 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % F
% Gly: 0 8 0 0 0 0 22 8 22 0 0 0 0 0 8 % G
% His: 0 0 22 8 0 0 0 22 0 0 8 65 0 8 0 % H
% Ile: 0 0 0 0 8 0 0 0 0 0 0 0 0 22 15 % I
% Lys: 72 0 0 50 0 58 0 0 8 8 0 8 0 0 0 % K
% Leu: 0 8 0 0 15 8 0 0 0 22 0 8 0 72 0 % L
% Met: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 43 0 0 0 8 0 0 % N
% Pro: 0 0 0 8 8 0 22 0 8 0 0 0 50 0 0 % P
% Gln: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 8 0 8 15 0 8 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 8 0 8 8 0 0 0 8 0 22 0 8 0 0 % S
% Thr: 0 43 0 8 0 0 0 0 0 0 0 0 0 0 22 % T
% Val: 15 0 0 8 0 22 0 0 0 58 0 22 22 0 58 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 58 0 0 0 0 72 0 8 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _