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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RHOT2 All Species: 20.61
Human Site: S588 Identified Species: 32.38
UniProt: Q8IXI1 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IXI1 NP_620124.1 618 68118 S588 H A E L H P S S F W L R G L L
Chimpanzee Pan troglodytes XP_510715 616 67803 S586 H A E L H P S S F W L R G L L
Rhesus Macaque Macaca mulatta XP_001118510 455 50332 G430 P S S F W L R G L L G V L G A
Dog Lupus familis XP_537019 616 67891 S586 H G E L H A T S F W L R V T L
Cat Felis silvestris
Mouse Mus musculus Q8JZN7 620 69053 S590 H T E L H P T S F W L R G V L
Rat Rattus norvegicus Q7TSA0 622 69135 P592 H T E L H P T P F W L R G V L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511136 687 78991 K593 Q N M D E M D K L K H E K K E
Chicken Gallus gallus Q5ZM83 618 69052 S591 A V E L G A A S F W L R V A L
Frog Xenopus laevis NP_001121318 618 70967 T591 Q A E L K N S T F W L R A S F
Zebra Danio Brachydanio rerio Q32LU1 617 69721 S590 G S D M S S T S F W L R V T L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q8IMX7 652 73757 L622 L M T E D P K L W L K A G L G
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q94263 625 70204 D600 R R V F Y L N D S N L L S K I
Sea Urchin Strong. purpuratus XP_791124 583 66070 P558 C T H Y G L P P P Q T F S S V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P39722 662 75132 E622 N T P G L P E E T A A K D V D
Red Bread Mold Neurospora crassa Q7RZA2 629 70228 D599 R S E E P P A D R A S L Y M A
Conservation
Percent
Protein Identity: 100 97.4 69.5 83.9 N.A. 85 84.2 N.A. 53.8 73.4 60.8 65.5 N.A. 47 N.A. 44.6 52.4
Protein Similarity: 100 97.9 70.3 87.8 N.A. 90.6 89.8 N.A. 67.6 83.5 75.2 77.8 N.A. 64.4 N.A. 62.5 65.8
P-Site Identity: 100 100 0 66.6 N.A. 80 73.3 N.A. 0 53.3 53.3 40 N.A. 20 N.A. 6.6 0
P-Site Similarity: 100 100 6.6 73.3 N.A. 93.3 86.6 N.A. 0 60 60 66.6 N.A. 26.6 N.A. 26.6 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 29.9 35.4
Protein Similarity: N.A. N.A. N.A. N.A. 47.5 54.8
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 13.3
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 20 0 0 0 14 14 0 0 14 7 7 7 7 14 % A
% Cys: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 7 7 7 0 7 14 0 0 0 0 7 0 7 % D
% Glu: 0 0 54 14 7 0 7 7 0 0 0 7 0 0 7 % E
% Phe: 0 0 0 14 0 0 0 0 54 0 0 7 0 0 7 % F
% Gly: 7 7 0 7 14 0 0 7 0 0 7 0 34 7 7 % G
% His: 34 0 7 0 34 0 0 0 0 0 7 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % I
% Lys: 0 0 0 0 7 0 7 7 0 7 7 7 7 14 0 % K
% Leu: 7 0 0 47 7 20 0 7 14 14 60 14 7 20 47 % L
% Met: 0 7 7 7 0 7 0 0 0 0 0 0 0 7 0 % M
% Asn: 7 7 0 0 0 7 7 0 0 7 0 0 0 0 0 % N
% Pro: 7 0 7 0 7 47 7 14 7 0 0 0 0 0 0 % P
% Gln: 14 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % Q
% Arg: 14 7 0 0 0 0 7 0 7 0 0 54 0 0 0 % R
% Ser: 0 20 7 0 7 7 20 40 7 0 7 0 14 14 0 % S
% Thr: 0 27 7 0 0 0 27 7 7 0 7 0 0 14 0 % T
% Val: 0 7 7 0 0 0 0 0 0 0 0 7 20 20 7 % V
% Trp: 0 0 0 0 7 0 0 0 7 54 0 0 0 0 0 % W
% Tyr: 0 0 0 7 7 0 0 0 0 0 0 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _