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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT2
All Species:
13.94
Human Site:
S25
Identified Species:
25.56
UniProt:
Q8IXJ6
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IXJ6
NP_036369.2
389
43182
S25
Q
E
A
Q
D
S
D
S
D
S
E
G
G
A
A
Chimpanzee
Pan troglodytes
XP_001168156
319
35635
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_855382
347
38546
R16
G
T
R
S
L
A
V
R
V
F
L
A
R
E
R
Cat
Felis silvestris
Mouse
Mus musculus
Q8VDQ8
389
43238
S25
Q
E
A
Q
D
S
D
S
D
T
E
G
G
A
T
Rat
Rattus norvegicus
Q5RJQ4
350
39301
E19
L
G
L
G
S
Q
K
E
R
L
L
D
E
L
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001017414
412
44719
A35
P
A
A
P
P
P
G
A
D
P
D
A
E
A
E
Frog
Xenopus laevis
NP_001088636
413
45548
S57
E
D
S
E
D
S
D
S
S
E
D
N
S
G
A
Zebra Danio
Brachydanio rerio
Q7ZVK3
379
42296
S25
L
E
G
Q
S
D
D
S
S
D
E
G
D
A
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650880
355
40094
V24
S
S
D
A
K
E
E
V
K
V
E
K
V
I
P
Honey Bee
Apis mellifera
XP_393038
355
40940
E24
T
N
I
S
S
E
Q
E
E
I
E
E
S
D
M
Nematode Worm
Caenorhab. elegans
Q21921
607
68747
T47
S
D
A
P
E
T
N
T
D
S
S
R
Q
R
T
Sea Urchin
Strong. purpuratus
XP_001195952
400
43895
S25
G
Q
S
E
S
V
D
S
Q
V
E
S
L
R
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53686
357
39961
A25
H
M
K
S
N
P
N
A
K
V
I
F
M
V
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
82
N.A.
75.8
N.A.
87.6
78.4
N.A.
N.A.
63.3
63.4
63.5
N.A.
43.7
47.5
25.2
47.2
Protein Similarity:
100
82
N.A.
82.2
N.A.
94.5
84.5
N.A.
N.A.
78.4
76
77.8
N.A.
59.6
61.4
39.8
64.7
P-Site Identity:
100
0
N.A.
0
N.A.
86.6
0
N.A.
N.A.
20
33.3
46.6
N.A.
6.6
6.6
20
20
P-Site Similarity:
100
0
N.A.
6.6
N.A.
93.3
0
N.A.
N.A.
33.3
66.6
53.3
N.A.
13.3
13.3
53.3
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
33.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
52.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
31
8
0
8
0
16
0
0
0
16
0
31
16
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
16
8
0
24
8
39
0
31
8
16
8
8
8
0
% D
% Glu:
8
24
0
16
8
16
8
16
8
8
47
8
16
8
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
8
0
8
0
0
0
% F
% Gly:
16
8
8
8
0
0
8
0
0
0
0
24
16
8
8
% G
% His:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
8
0
0
0
0
0
0
8
8
0
0
8
0
% I
% Lys:
0
0
8
0
8
0
8
0
16
0
0
8
0
0
0
% K
% Leu:
16
0
8
0
8
0
0
0
0
8
16
0
8
8
0
% L
% Met:
0
8
0
0
0
0
0
0
0
0
0
0
8
0
8
% M
% Asn:
0
8
0
0
8
0
16
0
0
0
0
8
0
0
8
% N
% Pro:
8
0
0
16
8
16
0
0
0
8
0
0
0
0
8
% P
% Gln:
16
8
0
24
0
8
8
0
8
0
0
0
8
0
0
% Q
% Arg:
0
0
8
0
0
0
0
8
8
0
0
8
8
16
8
% R
% Ser:
16
8
16
24
31
24
0
39
16
16
8
8
16
0
8
% S
% Thr:
8
8
0
0
0
8
0
8
0
8
0
0
0
0
24
% T
% Val:
0
0
0
0
0
8
8
8
8
24
0
0
8
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _