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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SIRT2 All Species: 20.91
Human Site: S98 Identified Species: 38.33
UniProt: Q8IXJ6 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IXJ6 NP_036369.2 389 43182 S98 A G I P D F R S P S T G L Y D
Chimpanzee Pan troglodytes XP_001168156 319 35635 H57 E I S Y F K K H P E P F F A L
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_855382 347 38546 E85 G Y F K K H P E P F F A L A K
Cat Felis silvestris
Mouse Mus musculus Q8VDQ8 389 43238 S98 A G I P D F R S P S T G L Y A
Rat Rattus norvegicus Q5RJQ4 350 39301 K88 I F E I S Y F K K H P E P F F
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001017414 412 44719 S112 A G I P D F R S P G T G L Y A
Frog Xenopus laevis NP_001088636 413 45548 S126 A G I P D F R S P G S G L Y S
Zebra Danio Brachydanio rerio Q7ZVK3 379 42296 S96 A G I P D F R S P G T G L Y A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_650880 355 40094 D93 P T A I F D L D Y F E K N P A
Honey Bee Apis mellifera XP_393038 355 40940 I93 G I S T S A G I P D F R S P T
Nematode Worm Caenorhab. elegans Q21921 607 68747 N131 P V R Q K L T N Y N S L A D A
Sea Urchin Strong. purpuratus XP_001195952 400 43895 T95 A G I P D F R T P G T G L Y D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P53686 357 39961 S94 Y P G N F R P S K F H Y L L K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 82 N.A. 75.8 N.A. 87.6 78.4 N.A. N.A. 63.3 63.4 63.5 N.A. 43.7 47.5 25.2 47.2
Protein Similarity: 100 82 N.A. 82.2 N.A. 94.5 84.5 N.A. N.A. 78.4 76 77.8 N.A. 59.6 61.4 39.8 64.7
P-Site Identity: 100 6.6 N.A. 13.3 N.A. 93.3 0 N.A. N.A. 86.6 80 86.6 N.A. 0 6.6 0 86.6
P-Site Similarity: 100 13.3 N.A. 13.3 N.A. 93.3 13.3 N.A. N.A. 86.6 86.6 86.6 N.A. 0 6.6 20 93.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 33.9 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 52.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 47 0 8 0 0 8 0 0 0 0 0 8 8 16 39 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 47 8 0 8 0 8 0 0 0 8 16 % D
% Glu: 8 0 8 0 0 0 0 8 0 8 8 8 0 0 0 % E
% Phe: 0 8 8 0 24 47 8 0 0 24 16 8 8 8 8 % F
% Gly: 16 47 8 0 0 0 8 0 0 31 0 47 0 0 0 % G
% His: 0 0 0 0 0 8 0 8 0 8 8 0 0 0 0 % H
% Ile: 8 16 47 16 0 0 0 8 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 8 16 8 8 8 16 0 0 8 0 0 16 % K
% Leu: 0 0 0 0 0 8 8 0 0 0 0 8 62 8 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 8 0 0 0 8 0 8 0 0 8 0 0 % N
% Pro: 16 8 0 47 0 0 16 0 70 0 16 0 8 16 0 % P
% Gln: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 8 0 0 8 47 0 0 0 0 8 0 0 0 % R
% Ser: 0 0 16 0 16 0 0 47 0 16 16 0 8 0 8 % S
% Thr: 0 8 0 8 0 0 8 8 0 0 39 0 0 0 8 % T
% Val: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 8 0 8 0 8 0 0 16 0 0 8 0 47 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _