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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT2
All Species:
3.03
Human Site:
T383
Identified Species:
5.56
UniProt:
Q8IXJ6
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IXJ6
NP_036369.2
389
43182
T383
A
K
D
E
A
R
T
T
E
R
E
K
P
Q
_
Chimpanzee
Pan troglodytes
XP_001168156
319
35635
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_855382
347
38546
Cat
Felis silvestris
Mouse
Mus musculus
Q8VDQ8
389
43238
K383
A
K
E
A
A
R
T
K
E
K
E
E
Q
Q
_
Rat
Rattus norvegicus
Q5RJQ4
350
39301
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001017414
412
44719
A396
T
D
G
S
G
G
R
A
E
S
S
G
A
S
S
Frog
Xenopus laevis
NP_001088636
413
45548
S402
N
S
S
K
E
E
S
S
A
A
N
T
S
D
D
Zebra Danio
Brachydanio rerio
Q7ZVK3
379
42296
A372
S
K
S
A
V
A
E
A
E
K
T
D
K
T
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650880
355
40094
Honey Bee
Apis mellifera
XP_393038
355
40940
Nematode Worm
Caenorhab. elegans
Q21921
607
68747
S563
S
L
D
D
F
V
L
S
D
E
D
R
K
N
T
Sea Urchin
Strong. purpuratus
XP_001195952
400
43895
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53686
357
39961
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
82
N.A.
75.8
N.A.
87.6
78.4
N.A.
N.A.
63.3
63.4
63.5
N.A.
43.7
47.5
25.2
47.2
Protein Similarity:
100
82
N.A.
82.2
N.A.
94.5
84.5
N.A.
N.A.
78.4
76
77.8
N.A.
59.6
61.4
39.8
64.7
P-Site Identity:
100
0
N.A.
0
N.A.
57.1
0
N.A.
N.A.
6.6
0
13.3
N.A.
0
0
6.6
0
P-Site Similarity:
100
0
N.A.
0
N.A.
78.5
0
N.A.
N.A.
6.6
20
26.6
N.A.
0
0
46.6
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
33.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
52.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
0
0
16
16
8
0
16
8
8
0
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
16
8
0
0
0
0
8
0
8
8
0
8
8
% D
% Glu:
0
0
8
8
8
8
8
0
31
8
16
8
0
0
8
% E
% Phe:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
8
0
8
8
0
0
0
0
0
8
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
24
0
8
0
0
0
8
0
16
0
8
16
0
0
% K
% Leu:
0
8
0
0
0
0
8
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
0
0
0
0
0
0
0
8
0
0
8
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
8
16
0
% Q
% Arg:
0
0
0
0
0
16
8
0
0
8
0
8
0
0
0
% R
% Ser:
16
8
16
8
0
0
8
16
0
8
8
0
8
8
8
% S
% Thr:
8
0
0
0
0
0
16
8
0
0
8
8
0
8
8
% T
% Val:
0
0
0
0
8
8
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
16
% _