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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PNPLA6 All Species: 36.06
Human Site: S626 Identified Species: 72.12
UniProt: Q8IY17 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IY17 NP_006693.3 1366 149995 S626 H T V A A R M S P F V R Q M D
Chimpanzee Pan troglodytes XP_512331 1484 162976 S744 H T V A A R M S P F V R Q M D
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_542111 1474 161798 S738 H T V A A R M S P F V R Q M D
Cat Felis silvestris
Mouse Mus musculus Q3TRM4 1355 149519 S616 H T V A A R M S P F V R Q M D
Rat Rattus norvegicus Q5BK26 1349 150006 S601 H T V V R R M S S F V R Q I D
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001106924 1321 147821 S604 H T V V T R M S P F V R Q M D
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001921208 1348 150755 S596 H T V A I R M S A F V R Q M D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9U969 1425 160554 S611 N G V V R R L S P L V R Q C D
Honey Bee Apis mellifera XP_001120383 1324 149002 S580 H S V V R R L S P F V R Q V D
Nematode Worm Caenorhab. elegans Q02331 1353 152377 V578 Y L P V A H S V L R R L S P F
Sea Urchin Strong. purpuratus XP_001202094 1454 161991 S677 H Q V V K K L S S F V R Q T D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7S8J1 1515 167542 S725 C V P G D D S S H D L L Q S S
Conservation
Percent
Protein Identity: 100 89 N.A. 88.1 N.A. 94.3 59.2 N.A. N.A. 77.1 N.A. 71.2 N.A. 40 45.2 33.1 43.9
Protein Similarity: 100 89.7 N.A. 90.2 N.A. 96.1 71.5 N.A. N.A. 84.7 N.A. 81.7 N.A. 58.1 61.4 51 60.8
P-Site Identity: 100 100 N.A. 100 N.A. 100 73.3 N.A. N.A. 86.6 N.A. 86.6 N.A. 53.3 66.6 6.6 53.3
P-Site Similarity: 100 100 N.A. 100 N.A. 100 80 N.A. N.A. 86.6 N.A. 86.6 N.A. 66.6 86.6 13.3 66.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. 28.7
Protein Similarity: N.A. N.A. N.A. N.A. N.A. 45
P-Site Identity: N.A. N.A. N.A. N.A. N.A. 13.3
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 42 42 0 0 0 9 0 0 0 0 0 0 % A
% Cys: 9 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % C
% Asp: 0 0 0 0 9 9 0 0 0 9 0 0 0 0 84 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 75 0 0 0 0 9 % F
% Gly: 0 9 0 9 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 75 0 0 0 0 9 0 0 9 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 9 0 0 0 0 0 0 0 0 9 0 % I
% Lys: 0 0 0 0 9 9 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 9 0 0 0 0 25 0 9 9 9 17 0 0 0 % L
% Met: 0 0 0 0 0 0 59 0 0 0 0 0 0 50 0 % M
% Asn: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 17 0 0 0 0 0 59 0 0 0 0 9 0 % P
% Gln: 0 9 0 0 0 0 0 0 0 0 0 0 92 0 0 % Q
% Arg: 0 0 0 0 25 75 0 0 0 9 9 84 0 0 0 % R
% Ser: 0 9 0 0 0 0 17 92 17 0 0 0 9 9 9 % S
% Thr: 0 59 0 0 9 0 0 0 0 0 0 0 0 9 0 % T
% Val: 0 9 84 50 0 0 0 9 0 0 84 0 0 9 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _