Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SMC5 All Species: 14.55
Human Site: S25 Identified Species: 29.09
UniProt: Q8IY18 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IY18 NP_055925.2 1101 128806 S25 R A L P R D P S S E V P S K R
Chimpanzee Pan troglodytes XP_520066 1204 140399 S128 R A L P R D P S S E V P S K R
Rhesus Macaque Macaca mulatta XP_001090492 1156 134111 S125 R A L P R D P S S E V P S K R
Dog Lupus familis XP_533529 1091 127678 P29 R D P S S E V P S K R K S S A
Cat Felis silvestris
Mouse Mus musculus Q8CG46 1101 128795 S25 R S L P R D A S S E V P S K R
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505381 1083 126056 G26 R K Q P S A G G S Q V P G A R
Chicken Gallus gallus Q5ZJY5 1065 124905 V28 H A G K P R S V E G S I V R I
Frog Xenopus laevis Q805A1 1065 124908 V27 Q E H H R N L V E G S I V R I
Zebra Danio Brachydanio rerio NP_001071040 697 80073
Tiger Blowfish Takifugu rubipres NP_001027801 1092 127634 S27 S N I G K I L S G H R P C G A
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786593 1069 124830 M26 D Y S Q D G Y M V G A I I R I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q08204 1093 126019 K31 S K R V K I A K P D L S S F Q
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 90.9 89.8 92.1 N.A. 89.6 N.A. N.A. 67.3 61.1 61.5 39.1 52.9 N.A. N.A. N.A. 38.1
Protein Similarity: 100 91.1 90.6 95.6 N.A. 95.8 N.A. N.A. 81.4 77.3 76.8 49.7 71.6 N.A. N.A. N.A. 59.5
P-Site Identity: 100 100 100 20 N.A. 86.6 N.A. N.A. 40 6.6 6.6 0 13.3 N.A. N.A. N.A. 0
P-Site Similarity: 100 100 100 33.3 N.A. 93.3 N.A. N.A. 46.6 13.3 26.6 0 26.6 N.A. N.A. N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 27.7 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 48.9 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 34 0 0 0 9 17 0 0 0 9 0 0 9 17 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % C
% Asp: 9 9 0 0 9 34 0 0 0 9 0 0 0 0 0 % D
% Glu: 0 9 0 0 0 9 0 0 17 34 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % F
% Gly: 0 0 9 9 0 9 9 9 9 25 0 0 9 9 0 % G
% His: 9 0 9 9 0 0 0 0 0 9 0 0 0 0 0 % H
% Ile: 0 0 9 0 0 17 0 0 0 0 0 25 9 0 25 % I
% Lys: 0 17 0 9 17 0 0 9 0 9 0 9 0 34 0 % K
% Leu: 0 0 34 0 0 0 17 0 0 0 9 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % M
% Asn: 0 9 0 0 0 9 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 9 42 9 0 25 9 9 0 0 50 0 0 0 % P
% Gln: 9 0 9 9 0 0 0 0 0 9 0 0 0 0 9 % Q
% Arg: 50 0 9 0 42 9 0 0 0 0 17 0 0 25 42 % R
% Ser: 17 9 9 9 17 0 9 42 50 0 17 9 50 9 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 9 0 0 9 17 9 0 42 0 17 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 9 0 0 0 0 9 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _