Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SMC5 All Species: 16.06
Human Site: S30 Identified Species: 32.12
UniProt: Q8IY18 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IY18 NP_055925.2 1101 128806 S30 D P S S E V P S K R K N S A P
Chimpanzee Pan troglodytes XP_520066 1204 140399 S133 D P S S E V P S K R K N S A P
Rhesus Macaque Macaca mulatta XP_001090492 1156 134111 S130 D P S S E V P S K R K N P A P
Dog Lupus familis XP_533529 1091 127678 S34 E V P S K R K S S A P P A P P
Cat Felis silvestris
Mouse Mus musculus Q8CG46 1101 128795 S30 D A S S E V P S K R K N S N P
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505381 1083 126056 G31 A G G S Q V P G A R R S R R P
Chicken Gallus gallus Q5ZJY5 1065 124905 V33 R S V E G S I V R I Y M E N F
Frog Xenopus laevis Q805A1 1065 124908 V32 N L V E G S I V R I K M E N F
Zebra Danio Brachydanio rerio NP_001071040 697 80073
Tiger Blowfish Takifugu rubipres NP_001027801 1092 127634 C32 I L S G H R P C G A E V E G R
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786593 1069 124830 I31 G Y M V G A I I R I K M V N F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q08204 1093 126019 S36 I A K P D L S S F Q P G S I I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 90.9 89.8 92.1 N.A. 89.6 N.A. N.A. 67.3 61.1 61.5 39.1 52.9 N.A. N.A. N.A. 38.1
Protein Similarity: 100 91.1 90.6 95.6 N.A. 95.8 N.A. N.A. 81.4 77.3 76.8 49.7 71.6 N.A. N.A. N.A. 59.5
P-Site Identity: 100 100 93.3 20 N.A. 86.6 N.A. N.A. 33.3 0 6.6 0 13.3 N.A. N.A. N.A. 6.6
P-Site Similarity: 100 100 93.3 40 N.A. 86.6 N.A. N.A. 53.3 6.6 20 0 20 N.A. N.A. N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 27.7 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 48.9 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 17 0 0 0 9 0 0 9 17 0 0 9 25 0 % A
% Cys: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % C
% Asp: 34 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 9 0 0 17 34 0 0 0 0 0 9 0 25 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 9 0 0 0 0 0 25 % F
% Gly: 9 9 9 9 25 0 0 9 9 0 0 9 0 9 0 % G
% His: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 17 0 0 0 0 0 25 9 0 25 0 0 0 9 9 % I
% Lys: 0 0 9 0 9 0 9 0 34 0 50 0 0 0 0 % K
% Leu: 0 17 0 0 0 9 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 9 0 0 0 0 0 0 0 0 25 0 0 0 % M
% Asn: 9 0 0 0 0 0 0 0 0 0 0 34 0 34 0 % N
% Pro: 0 25 9 9 0 0 50 0 0 0 17 9 9 9 50 % P
% Gln: 0 0 0 0 9 0 0 0 0 9 0 0 0 0 0 % Q
% Arg: 9 0 0 0 0 17 0 0 25 42 9 0 9 9 9 % R
% Ser: 0 9 42 50 0 17 9 50 9 0 0 9 34 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 9 17 9 0 42 0 17 0 0 0 9 9 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 9 0 0 0 0 0 0 0 0 9 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _