Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SMC5 All Species: 9.7
Human Site: S35 Identified Species: 19.39
UniProt: Q8IY18 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IY18 NP_055925.2 1101 128806 S35 V P S K R K N S A P Q L P L L
Chimpanzee Pan troglodytes XP_520066 1204 140399 S138 V P S K R K N S A P Q L P L L
Rhesus Macaque Macaca mulatta XP_001090492 1156 134111 P135 V P S K R K N P A P Q L P L V
Dog Lupus familis XP_533529 1091 127678 A39 R K S S A P P A P P P P P P L
Cat Felis silvestris
Mouse Mus musculus Q8CG46 1101 128795 S35 V P S K R K N S N P L P T L P
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505381 1083 126056 R36 V P G A R R S R R P P S P K W
Chicken Gallus gallus Q5ZJY5 1065 124905 E38 S I V R I Y M E N F L T Y D I
Frog Xenopus laevis Q805A1 1065 124908 E37 S I V R I K M E N F L T Y D Q
Zebra Danio Brachydanio rerio NP_001071040 697 80073
Tiger Blowfish Takifugu rubipres NP_001027801 1092 127634 E37 R P C G A E V E G R M D G S I
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786593 1069 124830 V36 A I I R I K M V N F V T Y D C
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q08204 1093 126019 S41 L S S F Q P G S I I K I R L Q
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 90.9 89.8 92.1 N.A. 89.6 N.A. N.A. 67.3 61.1 61.5 39.1 52.9 N.A. N.A. N.A. 38.1
Protein Similarity: 100 91.1 90.6 95.6 N.A. 95.8 N.A. N.A. 81.4 77.3 76.8 49.7 71.6 N.A. N.A. N.A. 59.5
P-Site Identity: 100 100 86.6 26.6 N.A. 66.6 N.A. N.A. 33.3 0 6.6 0 6.6 N.A. N.A. N.A. 6.6
P-Site Similarity: 100 100 93.3 33.3 N.A. 66.6 N.A. N.A. 46.6 13.3 13.3 0 20 N.A. N.A. N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 27.7 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 48.9 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 20 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 0 0 9 17 0 0 9 25 0 0 0 0 0 0 % A
% Cys: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 9 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 9 0 25 0 % D
% Glu: 0 0 0 0 0 9 0 25 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 9 0 0 0 0 0 25 0 0 0 0 0 % F
% Gly: 0 0 9 9 0 0 9 0 9 0 0 0 9 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 25 9 0 25 0 0 0 9 9 0 9 0 0 17 % I
% Lys: 0 9 0 34 0 50 0 0 0 0 9 0 0 9 0 % K
% Leu: 9 0 0 0 0 0 0 0 0 0 25 25 0 42 25 % L
% Met: 0 0 0 0 0 0 25 0 0 0 9 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 34 0 34 0 0 0 0 0 0 % N
% Pro: 0 50 0 0 0 17 9 9 9 50 17 17 42 9 9 % P
% Gln: 0 0 0 0 9 0 0 0 0 0 25 0 0 0 17 % Q
% Arg: 17 0 0 25 42 9 0 9 9 9 0 0 9 0 0 % R
% Ser: 17 9 50 9 0 0 9 34 0 0 0 9 0 9 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 25 9 0 0 % T
% Val: 42 0 17 0 0 0 9 9 0 0 9 0 0 0 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % W
% Tyr: 0 0 0 0 0 9 0 0 0 0 0 0 25 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _