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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC5
All Species:
20.3
Human Site:
S437
Identified Species:
40.61
UniProt:
Q8IY18
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IY18
NP_055925.2
1101
128806
S437
T
L
E
K
E
K
K
S
V
D
D
H
I
V
R
Chimpanzee
Pan troglodytes
XP_520066
1204
140399
S540
T
L
E
K
E
K
K
S
V
D
D
H
I
V
R
Rhesus Macaque
Macaca mulatta
XP_001090492
1156
134111
S537
T
L
E
K
E
K
K
S
V
D
D
H
I
V
R
Dog
Lupus familis
XP_533529
1091
127678
S441
S
L
E
K
E
R
K
S
V
G
D
N
I
V
R
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG46
1101
128795
S437
M
L
E
K
Q
R
R
S
V
S
D
H
I
T
R
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505381
1083
126056
S433
N
L
E
R
E
K
Q
S
M
T
D
H
I
Q
S
Chicken
Gallus gallus
Q5ZJY5
1065
124905
R416
N
Q
E
R
E
N
G
R
I
I
D
R
I
G
Q
Frog
Xenopus laevis
Q805A1
1065
124908
E417
N
L
E
R
E
K
K
E
K
A
N
R
I
K
Q
Zebra Danio
Brachydanio rerio
NP_001071040
697
80073
N133
T
R
E
I
Q
V
E
N
N
Q
S
T
W
M
L
Tiger Blowfish
Takifugu rubipres
NP_001027801
1092
127634
N434
R
S
L
Q
K
K
L
N
D
M
N
N
L
M
K
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786593
1069
124830
G421
A
L
K
K
E
I
R
G
Y
Q
D
R
L
K
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q08204
1093
126019
N427
S
E
I
D
A
K
A
N
A
I
N
H
E
M
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
90.9
89.8
92.1
N.A.
89.6
N.A.
N.A.
67.3
61.1
61.5
39.1
52.9
N.A.
N.A.
N.A.
38.1
Protein Similarity:
100
91.1
90.6
95.6
N.A.
95.8
N.A.
N.A.
81.4
77.3
76.8
49.7
71.6
N.A.
N.A.
N.A.
59.5
P-Site Identity:
100
100
100
73.3
N.A.
60
N.A.
N.A.
53.3
26.6
40
13.3
6.6
N.A.
N.A.
N.A.
33.3
P-Site Similarity:
100
100
100
93.3
N.A.
80
N.A.
N.A.
73.3
46.6
60
40
60
N.A.
N.A.
N.A.
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
27.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
48.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
0
9
0
9
0
9
9
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
9
0
0
0
0
9
25
67
0
0
0
0
% D
% Glu:
0
9
75
0
67
0
9
9
0
0
0
0
9
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
9
9
0
9
0
0
0
9
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
50
0
0
0
% H
% Ile:
0
0
9
9
0
9
0
0
9
17
0
0
67
0
0
% I
% Lys:
0
0
9
50
9
59
42
0
9
0
0
0
0
17
9
% K
% Leu:
0
67
9
0
0
0
9
0
0
0
0
0
17
0
9
% L
% Met:
9
0
0
0
0
0
0
0
9
9
0
0
0
25
0
% M
% Asn:
25
0
0
0
0
9
0
25
9
0
25
17
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
9
0
9
17
0
9
0
0
17
0
0
0
9
17
% Q
% Arg:
9
9
0
25
0
17
17
9
0
0
0
25
0
0
59
% R
% Ser:
17
9
0
0
0
0
0
50
0
9
9
0
0
0
9
% S
% Thr:
34
0
0
0
0
0
0
0
0
9
0
9
0
9
0
% T
% Val:
0
0
0
0
0
9
0
0
42
0
0
0
0
34
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _