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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC5
All Species:
18.79
Human Site:
T390
Identified Species:
37.58
UniProt:
Q8IY18
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IY18
NP_055925.2
1101
128806
T390
L
Q
N
E
L
K
T
T
E
N
C
E
N
L
Q
Chimpanzee
Pan troglodytes
XP_520066
1204
140399
T493
L
Q
N
E
L
K
T
T
E
N
C
E
N
L
Q
Rhesus Macaque
Macaca mulatta
XP_001090492
1156
134111
T490
L
Q
N
E
L
K
T
T
E
N
C
E
N
L
Q
Dog
Lupus familis
XP_533529
1091
127678
T394
L
Q
N
E
L
K
T
T
E
N
C
E
N
L
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG46
1101
128795
A390
L
Q
S
E
L
K
T
A
E
N
C
E
N
L
Q
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505381
1083
126056
T386
W
Q
S
E
L
K
N
T
G
S
S
E
N
L
Q
Chicken
Gallus gallus
Q5ZJY5
1065
124905
V369
W
N
N
E
L
N
T
V
T
D
C
E
N
L
Q
Frog
Xenopus laevis
Q805A1
1065
124908
M370
W
E
K
E
L
S
A
M
T
N
Q
E
N
I
Q
Zebra Danio
Brachydanio rerio
NP_001071040
697
80073
D97
T
S
V
L
G
R
G
D
K
V
G
L
Y
V
K
Tiger Blowfish
Takifugu rubipres
NP_001027801
1092
127634
V381
L
R
T
E
L
A
K
V
E
D
Q
P
D
V
T
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786593
1069
124830
L374
Y
E
R
E
L
D
Q
L
E
P
D
E
D
I
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q08204
1093
126019
T376
L
Q
A
T
I
I
S
T
K
E
D
F
L
R
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
90.9
89.8
92.1
N.A.
89.6
N.A.
N.A.
67.3
61.1
61.5
39.1
52.9
N.A.
N.A.
N.A.
38.1
Protein Similarity:
100
91.1
90.6
95.6
N.A.
95.8
N.A.
N.A.
81.4
77.3
76.8
49.7
71.6
N.A.
N.A.
N.A.
59.5
P-Site Identity:
100
100
100
100
N.A.
86.6
N.A.
N.A.
60
60
40
0
26.6
N.A.
N.A.
N.A.
26.6
P-Site Similarity:
100
100
100
100
N.A.
93.3
N.A.
N.A.
73.3
66.6
53.3
26.6
53.3
N.A.
N.A.
N.A.
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
27.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
48.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
0
0
9
9
9
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
50
0
0
0
0
% C
% Asp:
0
0
0
0
0
9
0
9
0
17
17
0
17
0
0
% D
% Glu:
0
17
0
84
0
0
0
0
59
9
0
75
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% F
% Gly:
0
0
0
0
9
0
9
0
9
0
9
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
9
9
0
0
0
0
0
0
0
17
0
% I
% Lys:
0
0
9
0
0
50
9
0
17
0
0
0
0
0
9
% K
% Leu:
59
0
0
9
84
0
0
9
0
0
0
9
9
59
0
% L
% Met:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% M
% Asn:
0
9
42
0
0
9
9
0
0
50
0
0
67
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
9
0
9
0
0
0
% P
% Gln:
0
59
0
0
0
0
9
0
0
0
17
0
0
0
67
% Q
% Arg:
0
9
9
0
0
9
0
0
0
0
0
0
0
9
9
% R
% Ser:
0
9
17
0
0
9
9
0
0
9
9
0
0
0
9
% S
% Thr:
9
0
9
9
0
0
50
50
17
0
0
0
0
0
9
% T
% Val:
0
0
9
0
0
0
0
17
0
9
0
0
0
17
0
% V
% Trp:
25
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _