KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC5
All Species:
32.42
Human Site:
T463
Identified Species:
64.85
UniProt:
Q8IY18
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IY18
NP_055925.2
1101
128806
T463
L
R
Q
R
F
R
D
T
Y
D
A
V
L
W
L
Chimpanzee
Pan troglodytes
XP_520066
1204
140399
T566
L
R
Q
R
F
R
D
T
Y
D
A
V
L
W
L
Rhesus Macaque
Macaca mulatta
XP_001090492
1156
134111
D554
N
L
M
N
Q
K
E
D
K
L
R
Q
R
F
R
Dog
Lupus familis
XP_533529
1091
127678
T467
L
R
Q
R
Y
R
D
T
Y
D
A
V
L
W
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG46
1101
128795
T463
L
R
Q
R
Y
R
D
T
Y
D
A
V
L
W
L
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505381
1083
126056
T459
L
K
G
R
Y
P
D
T
Y
N
A
I
M
W
L
Chicken
Gallus gallus
Q5ZJY5
1065
124905
T442
L
Q
A
R
F
R
D
T
H
S
A
L
M
W
L
Frog
Xenopus laevis
Q805A1
1065
124908
T443
L
K
R
M
Y
S
D
T
Y
N
A
V
V
W
L
Zebra Danio
Brachydanio rerio
NP_001071040
697
80073
K148
N
K
K
H
A
S
Q
K
A
V
E
E
A
V
R
Tiger Blowfish
Takifugu rubipres
NP_001027801
1092
127634
T454
L
R
G
R
H
R
D
T
H
A
A
L
Q
W
L
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786593
1069
124830
T447
L
K
T
R
S
P
D
T
Y
N
A
V
L
W
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q08204
1093
126019
V465
Q
D
Q
D
L
K
E
V
R
D
A
V
L
M
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
90.9
89.8
92.1
N.A.
89.6
N.A.
N.A.
67.3
61.1
61.5
39.1
52.9
N.A.
N.A.
N.A.
38.1
Protein Similarity:
100
91.1
90.6
95.6
N.A.
95.8
N.A.
N.A.
81.4
77.3
76.8
49.7
71.6
N.A.
N.A.
N.A.
59.5
P-Site Identity:
100
100
0
93.3
N.A.
93.3
N.A.
N.A.
53.3
60
53.3
0
60
N.A.
N.A.
N.A.
66.6
P-Site Similarity:
100
100
20
100
N.A.
100
N.A.
N.A.
86.6
86.6
86.6
13.3
73.3
N.A.
N.A.
N.A.
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
27.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
48.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
0
9
0
0
0
9
9
84
0
9
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
9
0
9
0
0
75
9
0
42
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
17
0
0
0
9
9
0
0
0
% E
% Phe:
0
0
0
0
25
0
0
0
0
0
0
0
0
9
0
% F
% Gly:
0
0
17
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
9
9
0
0
0
17
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% I
% Lys:
0
34
9
0
0
17
0
9
9
0
0
0
0
0
0
% K
% Leu:
75
9
0
0
9
0
0
0
0
9
0
17
50
0
75
% L
% Met:
0
0
9
9
0
0
0
0
0
0
0
0
17
9
0
% M
% Asn:
17
0
0
9
0
0
0
0
0
25
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
17
0
0
0
0
0
0
0
0
0
% P
% Gln:
9
9
42
0
9
0
9
0
0
0
0
9
9
0
0
% Q
% Arg:
0
42
9
67
0
50
0
0
9
0
9
0
9
0
17
% R
% Ser:
0
0
0
0
9
17
0
0
0
9
0
0
0
0
0
% S
% Thr:
0
0
9
0
0
0
0
75
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
9
0
9
0
59
9
9
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
75
0
% W
% Tyr:
0
0
0
0
34
0
0
0
59
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _