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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SMC5 All Species: 24.55
Human Site: T751 Identified Species: 49.09
UniProt: Q8IY18 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IY18 NP_055925.2 1101 128806 T751 V Q K A K L V T E L T N L I K
Chimpanzee Pan troglodytes XP_520066 1204 140399 T854 V Q K A K L V T E L T N L I K
Rhesus Macaque Macaca mulatta XP_001090492 1156 134111 T806 V Q K A K L V T E L T N L I K
Dog Lupus familis XP_533529 1091 127678 T755 V Q K A K L V T E L T N F V K
Cat Felis silvestris
Mouse Mus musculus Q8CG46 1101 128795 T751 V Q K A K L V T E L T G L V K
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505381 1083 126056 F747 I Q K T K L V F E Q T Q L I K
Chicken Gallus gallus Q5ZJY5 1065 124905 T730 I Q K A K L V T E L M C H I K
Frog Xenopus laevis Q805A1 1065 124908 K731 V Q K A K L V K D L L E L M K
Zebra Danio Brachydanio rerio NP_001071040 697 80073 E398 S A E K T K L E T D V R E S S
Tiger Blowfish Takifugu rubipres NP_001027801 1092 127634 K742 S Q K V T I V K A F I A S I K
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786593 1069 124830 K736 R K K L T I L K K I H D F N K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q08204 1093 126019 S763 L K Q R H L L S K M A S S M K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 90.9 89.8 92.1 N.A. 89.6 N.A. N.A. 67.3 61.1 61.5 39.1 52.9 N.A. N.A. N.A. 38.1
Protein Similarity: 100 91.1 90.6 95.6 N.A. 95.8 N.A. N.A. 81.4 77.3 76.8 49.7 71.6 N.A. N.A. N.A. 59.5
P-Site Identity: 100 100 100 86.6 N.A. 86.6 N.A. N.A. 66.6 73.3 66.6 0 33.3 N.A. N.A. N.A. 13.3
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 N.A. N.A. 73.3 80 80 13.3 40 N.A. N.A. N.A. 53.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 27.7 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 48.9 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 73.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 9 0 59 0 0 0 0 9 0 9 9 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 9 9 0 9 0 0 0 % D
% Glu: 0 0 9 0 0 0 0 9 59 0 0 9 9 0 0 % E
% Phe: 0 0 0 0 0 0 0 9 0 9 0 0 17 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % G
% His: 0 0 0 0 9 0 0 0 0 0 9 0 9 0 0 % H
% Ile: 17 0 0 0 0 17 0 0 0 9 9 0 0 50 0 % I
% Lys: 0 17 84 9 67 9 0 25 17 0 0 0 0 0 92 % K
% Leu: 9 0 0 9 0 75 25 0 0 59 9 0 50 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 9 9 0 0 17 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 34 0 9 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 75 9 0 0 0 0 0 0 9 0 9 0 0 0 % Q
% Arg: 9 0 0 9 0 0 0 0 0 0 0 9 0 0 0 % R
% Ser: 17 0 0 0 0 0 0 9 0 0 0 9 17 9 9 % S
% Thr: 0 0 0 9 25 0 0 50 9 0 50 0 0 0 0 % T
% Val: 50 0 0 9 0 0 75 0 0 0 9 0 0 17 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _