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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
6.06
Human Site:
S139
Identified Species:
9.52
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
S139
E
T
E
A
A
Y
E
S
D
I
P
E
E
L
C
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
Dog
Lupus familis
XP_852722
879
98718
L137
E
T
E
G
A
Y
E
L
D
L
P
E
E
L
C
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
Y137
D
K
E
I
E
A
T
Y
E
A
D
I
P
E
E
Rat
Rattus norvegicus
Q5U2P0
1054
120741
L196
L
D
N
F
W
P
D
L
K
A
A
H
E
L
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
S134
E
T
E
A
T
H
E
S
D
V
P
E
D
M
L
Frog
Xenopus laevis
Q6GN11
1040
119148
L227
E
Y
P
E
H
L
P
L
E
I
L
E
A
G
I
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
A225
V
Y
T
E
H
L
P
A
E
V
L
E
A
G
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
N246
R
Q
R
N
S
K
K
N
D
G
S
G
S
N
G
Honey Bee
Apis mellifera
XP_624734
786
91013
K110
R
I
N
P
W
C
H
K
Y
A
Y
L
S
L
S
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
E112
D
W
L
V
N
Y
V
E
Y
V
K
W
W
A
E
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
N109
M
S
S
L
Y
L
N
N
S
E
A
A
F
G
F
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
S143
M
K
G
S
N
V
P
S
N
N
P
T
A
E
D
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
E241
E
G
T
N
S
P
P
E
K
D
D
K
K
A
R
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
F295
G
S
V
S
L
P
R
F
S
K
P
V
L
I
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
0
80
N.A.
6.6
20
N.A.
N.A.
60
20
6.6
N.A.
6.6
6.6
6.6
0
P-Site Similarity:
100
N.A.
0
86.6
N.A.
20
26.6
N.A.
N.A.
86.6
26.6
26.6
N.A.
26.6
6.6
20
13.3
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
13.3
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
26.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
14
14
7
0
7
0
20
14
7
20
14
0
% A
% Cys:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
20
% C
% Asp:
14
7
0
0
0
0
7
0
27
7
14
0
7
0
7
% D
% Glu:
34
0
27
14
7
0
20
14
20
7
0
34
20
14
14
% E
% Phe:
0
0
0
7
0
0
0
7
0
0
0
0
7
0
7
% F
% Gly:
7
7
7
7
0
0
0
0
0
7
0
7
0
20
7
% G
% His:
0
0
0
0
14
7
7
0
0
0
0
7
0
0
0
% H
% Ile:
0
7
0
7
0
0
0
0
0
14
0
7
0
7
14
% I
% Lys:
0
14
0
0
0
7
7
7
14
7
7
7
7
0
0
% K
% Leu:
7
0
7
7
7
20
0
20
0
7
14
7
7
27
7
% L
% Met:
14
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% M
% Asn:
0
0
14
14
14
0
7
14
7
7
0
0
0
7
0
% N
% Pro:
0
0
7
7
0
20
27
0
0
0
34
0
7
0
0
% P
% Gln:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
14
0
7
0
0
0
7
0
0
0
0
0
0
0
7
% R
% Ser:
0
14
7
14
14
0
0
20
14
0
7
0
14
0
7
% S
% Thr:
0
20
14
0
7
0
7
0
0
0
0
7
0
0
0
% T
% Val:
7
0
7
7
0
7
7
0
0
20
0
7
0
0
7
% V
% Trp:
0
7
0
0
14
0
0
0
0
0
0
7
7
0
0
% W
% Tyr:
0
14
0
0
7
20
0
7
14
0
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _