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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
10.91
Human Site:
S161
Identified Species:
17.14
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
S161
S
L
K
S
Y
N
D
S
P
D
V
I
V
E
A
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
Dog
Lupus familis
XP_852722
879
98718
S159
S
M
K
G
Y
N
D
S
P
D
V
I
I
E
A
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
S159
Q
Q
S
R
K
G
W
S
G
P
D
V
I
I
E
Rat
Rattus norvegicus
Q5U2P0
1054
120741
Q218
R
E
R
E
S
E
S
Q
E
T
H
G
K
E
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
S156
A
A
K
G
D
A
K
S
P
D
V
I
I
E
A
Frog
Xenopus laevis
Q6GN11
1040
119148
H249
G
V
L
S
V
N
K
H
R
A
Q
L
E
S
F
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
H247
G
I
L
S
V
N
K
H
R
A
Q
H
E
A
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
I268
L
E
A
M
R
S
Y
I
N
K
I
V
Q
R
H
Honey Bee
Apis mellifera
XP_624734
786
91013
N132
I
V
G
L
R
D
R
N
R
A
F
D
G
D
F
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
S134
S
G
K
T
D
N
N
S
P
N
K
T
E
K
R
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
G131
G
E
E
Q
D
K
V
G
D
L
V
R
R
E
W
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
G165
N
G
K
C
A
D
F
G
N
S
L
V
P
Q
K
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
F263
V
E
G
F
E
D
G
F
S
K
N
K
S
S
V
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
I317
A
F
N
G
D
Q
V
I
V
E
L
L
P
Q
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
0
80
N.A.
6.6
6.6
N.A.
N.A.
53.3
13.3
13.3
N.A.
0
0
33.3
13.3
P-Site Similarity:
100
N.A.
0
93.3
N.A.
20
13.3
N.A.
N.A.
66.6
26.6
20
N.A.
20
26.6
60
20
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
6.6
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
40
N.A.
N.A.
6.6
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
7
7
0
7
7
0
0
0
20
0
0
0
7
20
% A
% Cys:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
27
20
14
0
7
20
7
7
0
7
0
% D
% Glu:
0
27
7
7
7
7
0
0
7
7
0
0
20
34
7
% E
% Phe:
0
7
0
7
0
0
7
7
0
0
7
0
0
0
20
% F
% Gly:
20
14
14
20
0
7
7
14
7
0
0
7
7
0
0
% G
% His:
0
0
0
0
0
0
0
14
0
0
7
7
0
0
7
% H
% Ile:
7
7
0
0
0
0
0
14
0
0
7
20
20
7
0
% I
% Lys:
0
0
34
0
7
7
20
0
0
14
7
7
7
7
7
% K
% Leu:
7
7
14
7
0
0
0
0
0
7
14
14
0
0
0
% L
% Met:
0
7
0
7
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
0
7
0
0
34
7
7
14
7
7
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
27
7
0
0
14
0
0
% P
% Gln:
7
7
0
7
0
7
0
7
0
0
14
0
7
14
0
% Q
% Arg:
7
0
7
7
14
0
7
0
20
0
0
7
7
7
7
% R
% Ser:
20
0
7
20
7
7
7
34
7
7
0
0
7
14
7
% S
% Thr:
0
0
0
7
0
0
0
0
0
7
0
7
0
0
0
% T
% Val:
7
14
0
0
14
0
14
0
7
0
27
20
7
0
7
% V
% Trp:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
7
% W
% Tyr:
0
0
0
0
14
0
7
0
0
0
0
0
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _