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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
4.85
Human Site:
S173
Identified Species:
7.62
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
0.29
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
S173
V
E
A
Q
F
D
G
S
D
S
E
D
G
H
G
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
Dog
Lupus familis
XP_852722
879
98718
S171
I
E
A
Q
F
D
D
S
D
S
E
D
G
H
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
D171
I
I
E
A
Q
F
D
D
S
D
S
E
D
R
H
Rat
Rattus norvegicus
Q5U2P0
1054
120741
P230
K
E
Y
P
E
H
L
P
L
E
V
L
E
A
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
D168
I
E
A
Q
F
D
D
D
D
A
E
H
G
Q
D
Frog
Xenopus laevis
Q6GN11
1040
119148
G261
E
S
F
V
R
L
Q
G
L
G
G
K
E
T
D
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
G259
E
A
F
V
R
Y
E
G
S
A
S
K
N
T
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
H280
Q
R
H
V
G
M
D
H
Q
L
S
E
D
L
I
Honey Bee
Apis mellifera
XP_624734
786
91013
I144
G
D
F
V
V
A
C
I
N
Q
P
E
K
W
Q
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
E146
E
K
R
C
L
R
N
E
I
Q
D
N
G
V
T
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
S143
R
E
W
S
D
A
R
S
E
V
S
S
S
S
E
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
D177
P
Q
K
G
I
H
Y
D
E
T
A
C
A
G
E
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
A275
S
S
V
I
G
K
G
A
K
N
G
V
T
P
S
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
P329
P
Q
S
E
W
K
A
P
S
S
I
V
L
D
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
0
80
N.A.
0
13.3
N.A.
N.A.
53.3
0
0
N.A.
0
0
6.6
13.3
P-Site Similarity:
100
N.A.
0
86.6
N.A.
13.3
13.3
N.A.
N.A.
66.6
0
6.6
N.A.
6.6
20
26.6
20
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
0
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
20
N.A.
N.A.
20
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
20
7
0
14
7
7
0
14
7
0
7
7
0
% A
% Cys:
0
0
0
7
0
0
7
0
0
0
0
7
0
0
0
% C
% Asp:
0
7
0
0
7
20
27
20
20
7
7
14
14
7
14
% D
% Glu:
20
34
7
7
7
0
7
7
14
7
20
20
14
0
20
% E
% Phe:
0
0
20
0
20
7
0
0
0
0
0
0
0
0
0
% F
% Gly:
7
0
0
7
14
0
14
14
0
7
14
0
27
7
14
% G
% His:
0
0
7
0
0
14
0
7
0
0
0
7
0
14
7
% H
% Ile:
20
7
0
7
7
0
0
7
7
0
7
0
0
0
7
% I
% Lys:
7
7
7
0
0
14
0
0
7
0
0
14
7
0
0
% K
% Leu:
0
0
0
0
7
7
7
0
14
7
0
7
7
7
0
% L
% Met:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
7
0
7
7
0
7
7
0
0
% N
% Pro:
14
0
0
7
0
0
0
14
0
0
7
0
0
7
0
% P
% Gln:
7
14
0
20
7
0
7
0
7
14
0
0
0
7
7
% Q
% Arg:
7
7
7
0
14
7
7
0
0
0
0
0
0
7
0
% R
% Ser:
7
14
7
7
0
0
0
20
20
20
27
7
7
7
20
% S
% Thr:
0
0
0
0
0
0
0
0
0
7
0
0
7
14
7
% T
% Val:
7
0
7
27
7
0
0
0
0
7
7
14
0
7
0
% V
% Trp:
0
0
7
0
7
0
0
0
0
0
0
0
0
7
0
% W
% Tyr:
0
0
7
0
0
7
7
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _