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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
10.61
Human Site:
S194
Identified Species:
16.67
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
S194
V
D
G
V
K
K
L
S
V
C
V
S
E
K
G
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
Dog
Lupus familis
XP_852722
879
98718
S192
V
D
G
V
K
K
L
S
V
C
V
H
D
K
G
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
S192
V
D
G
V
K
K
L
S
I
S
T
P
D
R
G
Rat
Rattus norvegicus
Q5U2P0
1054
120741
N251
I
Q
G
I
L
N
V
N
K
H
R
A
Q
I
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
S189
A
R
D
I
K
T
L
S
L
D
T
A
E
K
G
Frog
Xenopus laevis
Q6GN11
1040
119148
N282
I
H
G
T
K
P
R
N
R
A
I
H
G
D
L
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
N280
I
N
G
A
K
H
R
N
R
A
V
H
G
D
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
R301
D
L
E
A
H
A
Q
R
L
V
A
A
G
Y
G
Honey Bee
Apis mellifera
XP_624734
786
91013
C165
Q
K
T
G
V
V
V
C
I
R
E
K
I
H
P
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
A167
S
C
L
I
T
I
G
A
I
V
H
I
L
E
K
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
G164
R
T
P
S
N
N
R
G
S
S
T
S
G
G
G
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
A198
V
N
G
Y
H
Q
S
A
S
E
S
S
L
A
V
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
E296
S
C
L
G
S
F
C
E
Q
K
G
N
C
S
A
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
G350
D
N
P
D
I
E
A
G
D
D
D
D
N
N
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
0
86.6
N.A.
60
6.6
N.A.
N.A.
40
13.3
20
N.A.
6.6
0
0
13.3
P-Site Similarity:
100
N.A.
0
93.3
N.A.
80
46.6
N.A.
N.A.
60
33.3
40
N.A.
20
13.3
26.6
13.3
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
20
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
40
N.A.
N.A.
6.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
14
0
7
7
14
0
14
7
20
0
7
7
% A
% Cys:
0
14
0
0
0
0
7
7
0
14
0
0
7
0
0
% C
% Asp:
14
20
7
7
0
0
0
0
7
14
7
7
14
14
0
% D
% Glu:
0
0
7
0
0
7
0
7
0
7
7
0
14
7
14
% E
% Phe:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
47
14
0
0
7
14
0
0
7
0
27
7
40
% G
% His:
0
7
0
0
14
7
0
0
0
7
7
20
0
7
0
% H
% Ile:
20
0
0
20
7
7
0
0
20
0
7
7
7
7
0
% I
% Lys:
0
7
0
0
40
20
0
0
7
7
0
7
0
20
7
% K
% Leu:
0
7
14
0
7
0
27
0
14
0
0
0
14
0
7
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
20
0
0
7
14
0
20
0
0
0
7
7
7
0
% N
% Pro:
0
0
14
0
0
7
0
0
0
0
0
7
0
0
7
% P
% Gln:
7
7
0
0
0
7
7
0
7
0
0
0
7
0
0
% Q
% Arg:
7
7
0
0
0
0
20
7
14
7
7
0
0
7
0
% R
% Ser:
14
0
0
7
7
0
7
27
14
14
7
20
0
7
0
% S
% Thr:
0
7
7
7
7
7
0
0
0
0
20
0
0
0
0
% T
% Val:
27
0
0
20
7
7
14
0
14
14
20
0
0
0
14
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
7
0
0
0
0
0
0
0
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _