KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
7.58
Human Site:
S20
Identified Species:
11.9
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
S20
L
G
T
P
R
G
V
S
A
V
A
G
P
H
D
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
Dog
Lupus familis
XP_852722
879
98718
P23
G
V
S
S
V
A
G
P
H
G
V
G
A
S
P
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
S20
P
G
T
P
R
G
V
S
S
V
V
G
P
S
A
Rat
Rattus norvegicus
Q5U2P0
1054
120741
P29
V
R
E
H
Y
L
R
P
S
V
P
C
N
S
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
S20
L
G
T
P
R
G
G
S
Y
A
A
V
P
T
S
Frog
Xenopus laevis
Q6GN11
1040
119148
A35
E
D
V
R
C
G
S
A
L
C
H
T
C
P
R
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
S102
R
H
Y
N
R
L
R
S
L
L
K
D
P
R
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
N20
M
S
E
T
S
S
V
N
V
D
A
D
R
D
C
Honey Bee
Apis mellifera
XP_624734
786
91013
E20
Q
N
Q
F
T
F
A
E
K
F
A
H
K
I
S
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
N22
Y
V
K
P
Q
N
A
N
N
L
Q
N
N
F
N
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
G20
A
R
N
R
A
L
Q
G
D
V
V
A
V
Q
I
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
K32
L
D
G
S
M
L
A
K
S
C
T
E
P
I
V
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
S118
S
K
Q
L
L
S
K
S
C
P
D
P
R
A
C
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
I166
E
R
L
P
N
E
T
I
N
D
R
N
D
R
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
0
6.6
N.A.
66.6
6.6
N.A.
N.A.
60
6.6
20
N.A.
13.3
6.6
6.6
6.6
P-Site Similarity:
100
N.A.
0
13.3
N.A.
73.3
20
N.A.
N.A.
60
13.3
26.6
N.A.
26.6
6.6
33.3
6.6
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
13.3
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
20
N.A.
N.A.
6.6
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
7
7
20
7
7
7
27
7
7
7
14
% A
% Cys:
0
0
0
0
7
0
0
0
7
14
0
7
7
0
14
% C
% Asp:
0
14
0
0
0
0
0
0
7
14
7
14
7
7
7
% D
% Glu:
14
0
14
0
0
7
0
7
0
0
0
7
0
0
0
% E
% Phe:
0
0
0
7
0
7
0
0
0
7
0
0
0
7
0
% F
% Gly:
7
20
7
0
0
27
14
7
0
7
0
20
0
0
0
% G
% His:
0
7
0
7
0
0
0
0
7
0
7
7
0
7
7
% H
% Ile:
0
0
0
0
0
0
0
7
0
0
0
0
0
14
7
% I
% Lys:
0
7
7
0
0
0
7
7
7
0
7
0
7
0
0
% K
% Leu:
20
0
7
7
7
27
0
0
14
14
0
0
0
0
0
% L
% Met:
7
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
7
7
7
7
7
0
14
14
0
0
14
14
0
7
% N
% Pro:
7
0
0
34
0
0
0
14
0
7
7
7
34
7
14
% P
% Gln:
7
0
14
0
7
0
7
0
0
0
7
0
0
7
0
% Q
% Arg:
7
20
0
14
27
0
14
0
0
0
7
0
14
14
7
% R
% Ser:
7
7
7
14
7
14
7
34
20
0
0
0
0
20
14
% S
% Thr:
0
0
20
7
7
0
7
0
0
0
7
7
0
7
0
% T
% Val:
7
14
7
0
7
0
20
0
7
27
20
7
7
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
7
0
7
0
0
0
7
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _