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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
8.79
Human Site:
S218
Identified Species:
13.81
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
S218
K
D
E
T
T
C
I
S
Q
D
T
R
A
L
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
Dog
Lupus familis
XP_852722
879
98718
S216
K
E
E
S
T
S
T
S
Q
D
T
R
A
S
P
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
P216
K
D
E
N
T
P
I
P
Q
D
T
R
G
L
S
Rat
Rattus norvegicus
Q5U2P0
1054
120741
S275
S
K
D
S
G
L
V
S
D
I
L
I
H
G
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
T213
Q
E
E
V
P
K
A
T
P
D
P
K
L
L
P
Frog
Xenopus laevis
Q6GN11
1040
119148
A306
E
W
K
G
R
T
G
A
L
C
E
N
E
T
D
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
A304
E
W
K
G
R
T
M
A
L
T
E
G
Q
G
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
A325
N
R
K
N
N
R
Q
A
F
I
I
M
S
T
D
Honey Bee
Apis mellifera
XP_624734
786
91013
Y189
R
G
A
F
T
F
F
Y
P
R
D
H
R
V
P
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
A191
L
Q
L
M
P
N
S
A
N
P
N
V
L
F
V
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
P188
G
N
D
P
R
M
A
P
K
T
A
R
V
V
Y
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
A222
N
S
V
G
R
I
C
A
M
L
S
L
Y
P
S
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
T320
S
F
P
H
K
R
P
T
G
Q
V
V
A
V
V
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
A374
D
K
Q
R
R
L
L
A
K
D
A
M
I
A
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
0
60
N.A.
73.3
13.3
N.A.
N.A.
20
0
0
N.A.
0
6.6
0
6.6
P-Site Similarity:
100
N.A.
0
73.3
N.A.
73.3
33.3
N.A.
N.A.
46.6
20
26.6
N.A.
20
20
6.6
33.3
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
6.6
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
20
N.A.
N.A.
20
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
0
0
14
40
0
0
14
0
20
7
0
% A
% Cys:
0
0
0
0
0
7
7
0
0
7
0
0
0
0
0
% C
% Asp:
7
14
14
0
0
0
0
0
7
34
7
0
0
0
14
% D
% Glu:
14
14
27
0
0
0
0
0
0
0
14
0
7
0
7
% E
% Phe:
0
7
0
7
0
7
7
0
7
0
0
0
0
7
0
% F
% Gly:
7
7
0
20
7
0
7
0
7
0
0
7
7
14
0
% G
% His:
0
0
0
7
0
0
0
0
0
0
0
7
7
0
0
% H
% Ile:
0
0
0
0
0
7
14
0
0
14
7
7
7
0
0
% I
% Lys:
20
14
20
0
7
7
0
0
14
0
0
7
0
0
0
% K
% Leu:
7
0
7
0
0
14
7
0
14
7
7
7
14
20
0
% L
% Met:
0
0
0
7
0
7
7
0
7
0
0
14
0
0
0
% M
% Asn:
14
7
0
14
7
7
0
0
7
0
7
7
0
0
0
% N
% Pro:
0
0
7
7
14
7
7
14
14
7
7
0
0
7
20
% P
% Gln:
7
7
7
0
0
0
7
0
20
7
0
0
7
0
7
% Q
% Arg:
7
7
0
7
34
14
0
0
0
7
0
27
7
0
0
% R
% Ser:
14
7
0
14
0
7
7
20
0
0
7
0
7
7
27
% S
% Thr:
0
0
0
7
27
14
7
14
0
14
20
0
0
14
0
% T
% Val:
0
0
7
7
0
0
7
0
0
0
7
14
7
20
14
% V
% Trp:
0
14
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
7
0
0
0
0
7
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _