KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
14.85
Human Site:
S232
Identified Species:
23.33
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
S232
S
E
K
S
L
Q
R
S
A
K
V
V
Y
I
L
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
Dog
Lupus familis
XP_852722
879
98718
S230
P
E
K
S
L
Q
R
S
A
K
V
V
Y
I
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
S230
S
E
K
S
L
Q
K
S
A
K
V
V
Y
I
L
Rat
Rattus norvegicus
Q5U2P0
1054
120741
I289
S
K
A
R
N
R
S
I
H
G
D
V
V
V
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
T227
P
D
K
F
L
Q
R
T
A
K
V
V
Y
I
L
Frog
Xenopus laevis
Q6GN11
1040
119148
Q320
D
E
K
V
G
D
M
Q
A
E
V
M
P
T
G
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
T318
E
E
R
P
L
E
D
T
Q
S
Q
P
M
P
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
D339
D
R
E
A
L
E
R
D
G
I
V
L
L
P
V
Honey Bee
Apis mellifera
XP_624734
786
91013
E203
P
L
V
K
I
N
R
E
S
L
Q
Q
F
A
V
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
P205
V
A
T
D
S
R
V
P
R
I
L
I
P
K
S
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
S202
Y
I
C
E
Y
K
H
S
R
A
A
S
G
H
L
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
V236
S
K
R
P
T
G
R
V
V
A
I
V
E
K
S
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
D334
V
E
K
S
L
V
R
D
S
I
V
G
L
L
D
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
P388
Q
R
S
K
K
I
Q
P
T
A
K
V
V
Y
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
0
86.6
N.A.
93.3
13.3
N.A.
N.A.
73.3
26.6
13.3
N.A.
20
6.6
0
13.3
P-Site Similarity:
100
N.A.
0
86.6
N.A.
100
40
N.A.
N.A.
86.6
40
33.3
N.A.
53.3
33.3
20
20
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
20
N.A.
N.A.
40
6.6
N.A.
P-Site Similarity:
40
N.A.
N.A.
53.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
7
7
0
0
0
0
34
20
7
0
0
7
0
% A
% Cys:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
14
7
0
7
0
7
7
14
0
0
7
0
0
0
7
% D
% Glu:
7
40
7
7
0
14
0
7
0
7
0
0
7
0
0
% E
% Phe:
0
0
0
7
0
0
0
0
0
0
0
0
7
0
0
% F
% Gly:
0
0
0
0
7
7
0
0
7
7
0
7
7
0
7
% G
% His:
0
0
0
0
0
0
7
0
7
0
0
0
0
7
0
% H
% Ile:
0
7
0
0
7
7
0
7
0
20
7
7
0
27
7
% I
% Lys:
0
14
40
14
7
7
7
0
0
27
7
0
0
14
0
% K
% Leu:
0
7
0
0
47
0
0
0
0
7
7
7
14
7
27
% L
% Met:
0
0
0
0
0
0
7
0
0
0
0
7
7
0
0
% M
% Asn:
0
0
0
0
7
7
0
0
0
0
0
0
0
0
0
% N
% Pro:
20
0
0
14
0
0
0
14
0
0
0
7
14
14
0
% P
% Gln:
7
0
0
0
0
27
7
7
7
0
14
7
0
0
0
% Q
% Arg:
0
14
14
7
0
14
47
0
14
0
0
0
0
0
0
% R
% Ser:
27
0
7
27
7
0
7
27
14
7
0
7
0
0
20
% S
% Thr:
0
0
7
0
7
0
0
14
7
0
0
0
0
7
7
% T
% Val:
14
0
7
7
0
7
7
7
7
0
47
47
14
7
20
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
0
7
0
0
0
0
0
0
0
27
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _