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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
13.94
Human Site:
S244
Identified Species:
21.9
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
S244
Y
I
L
E
K
K
H
S
R
A
A
T
G
F
L
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
L10
H
P
D
Y
R
M
N
L
R
P
L
G
T
P
R
Dog
Lupus familis
XP_852722
879
98718
S242
Y
I
S
E
K
K
H
S
R
A
A
T
G
F
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
S242
Y
I
L
E
K
K
H
S
R
A
A
T
G
I
L
Rat
Rattus norvegicus
Q5U2P0
1054
120741
K301
V
V
V
E
L
L
P
K
S
E
W
K
G
R
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
S239
Y
I
L
E
K
K
H
S
R
A
A
T
G
F
I
Frog
Xenopus laevis
Q6GN11
1040
119148
I332
P
T
G
R
V
V
G
I
M
Q
R
N
W
R
D
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
E330
M
P
T
G
R
V
V
E
I
L
Q
R
N
W
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
A351
L
P
V
A
R
R
Y
A
F
D
G
D
K
V
R
Honey Bee
Apis mellifera
XP_624734
786
91013
Y215
F
A
V
C
P
S
S
Y
E
D
T
L
Y
L
V
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
E217
P
K
S
D
V
D
K
E
F
F
S
R
P
K
D
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
N214
G
H
L
K
L
P
S
N
P
R
A
P
D
V
M
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
V248
E
K
S
P
R
R
D
V
I
V
G
F
L
N
V
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
I346
L
L
D
V
K
G
W
I
H
Y
K
E
S
D
P
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
W400
V
Y
I
Q
R
R
S
W
R
Q
Y
V
G
Q
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
6.6
93.3
N.A.
93.3
13.3
N.A.
N.A.
93.3
0
0
N.A.
0
0
0
13.3
P-Site Similarity:
100
N.A.
26.6
93.3
N.A.
93.3
26.6
N.A.
N.A.
100
0
13.3
N.A.
33.3
20
13.3
33.3
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
0
N.A.
N.A.
6.6
20
N.A.
P-Site Similarity:
20
N.A.
N.A.
13.3
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
7
0
0
0
7
0
27
34
0
0
0
0
% A
% Cys:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
14
7
0
7
7
0
0
14
0
7
7
7
14
% D
% Glu:
7
0
0
34
0
0
0
14
7
7
0
7
0
0
0
% E
% Phe:
7
0
0
0
0
0
0
0
14
7
0
7
0
20
0
% F
% Gly:
7
0
7
7
0
7
7
0
0
0
14
7
40
0
0
% G
% His:
7
7
0
0
0
0
27
0
7
0
0
0
0
0
0
% H
% Ile:
0
27
7
0
0
0
0
14
14
0
0
0
0
7
7
% I
% Lys:
0
14
0
7
34
27
7
7
0
0
7
7
7
7
0
% K
% Leu:
14
7
27
0
14
7
0
7
0
7
7
7
7
7
27
% L
% Met:
7
0
0
0
0
7
0
0
7
0
0
0
0
0
7
% M
% Asn:
0
0
0
0
0
0
7
7
0
0
0
7
7
7
0
% N
% Pro:
14
20
0
7
7
7
7
0
7
7
0
7
7
7
7
% P
% Gln:
0
0
0
7
0
0
0
0
0
14
7
0
0
7
0
% Q
% Arg:
0
0
0
7
34
20
0
0
40
7
7
14
0
14
20
% R
% Ser:
0
0
20
0
0
7
20
27
7
0
7
0
7
0
0
% S
% Thr:
0
7
7
0
0
0
0
0
0
0
7
27
7
0
7
% T
% Val:
14
7
20
7
14
14
7
7
0
7
0
7
0
14
14
% V
% Trp:
0
0
0
0
0
0
7
7
0
0
7
0
7
7
0
% W
% Tyr:
27
7
0
7
0
0
7
7
0
7
7
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _