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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
16.06
Human Site:
S259
Identified Species:
25.24
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
S259
K
L
L
A
D
K
N
S
E
L
F
R
K
Y
A
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
P25
G
V
S
T
V
A
G
P
H
D
I
G
A
S
P
Dog
Lupus familis
XP_852722
879
98718
S257
K
L
L
A
D
K
N
S
E
L
F
R
K
Y
A
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
S257
K
L
L
A
D
K
N
S
D
L
F
K
K
Y
A
Rat
Rattus norvegicus
Q5U2P0
1054
120741
S316
A
A
L
C
E
N
D
S
E
D
K
A
S
G
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
S254
K
L
L
A
D
K
N
S
E
L
F
K
K
C
A
Frog
Xenopus laevis
Q6GN11
1040
119148
K347
Y
V
V
T
F
P
A
K
E
D
T
E
T
Q
G
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
P345
D
Y
V
V
T
L
P
P
F
E
E
M
Q
S
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
A366
A
F
V
L
N
P
G
A
Q
G
S
S
K
T
A
Honey Bee
Apis mellifera
XP_624734
786
91013
P230
V
I
T
D
W
I
K
P
K
F
A
V
G
K
I
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
A232
F
E
R
F
L
Y
T
A
K
I
T
D
W
R
A
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
V229
F
A
P
T
D
H
R
V
P
R
I
Y
I
P
R
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
E263
K
Q
W
F
Y
Y
R
E
G
C
R
Q
N
A
K
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
S361
K
R
C
K
S
P
L
S
L
S
D
D
E
Y
V
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
Q415
A
P
S
S
V
D
P
Q
S
S
S
T
Q
N
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
0
100
N.A.
86.6
20
N.A.
N.A.
86.6
6.6
0
N.A.
13.3
0
6.6
6.6
P-Site Similarity:
100
N.A.
6.6
100
N.A.
100
33.3
N.A.
N.A.
93.3
20
13.3
N.A.
40
13.3
26.6
6.6
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
6.6
N.A.
N.A.
20
0
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
26.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
14
0
27
0
7
7
14
0
0
7
7
7
7
40
% A
% Cys:
0
0
7
7
0
0
0
0
0
7
0
0
0
7
0
% C
% Asp:
7
0
0
7
34
7
7
0
7
20
7
14
0
0
0
% D
% Glu:
0
7
0
0
7
0
0
7
34
7
7
7
7
0
7
% E
% Phe:
14
7
0
14
7
0
0
0
7
7
27
0
0
0
0
% F
% Gly:
7
0
0
0
0
0
14
0
7
7
0
7
7
7
7
% G
% His:
0
0
0
0
0
7
0
0
7
0
0
0
0
0
0
% H
% Ile:
0
7
0
0
0
7
0
0
0
7
14
0
7
0
7
% I
% Lys:
40
0
0
7
0
27
7
7
14
0
7
14
34
7
7
% K
% Leu:
0
27
34
7
7
7
7
0
7
27
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% M
% Asn:
0
0
0
0
7
7
27
0
0
0
0
0
7
7
0
% N
% Pro:
0
7
7
0
0
20
14
20
7
0
0
0
0
7
7
% P
% Gln:
0
7
0
0
0
0
0
7
7
0
0
7
14
7
7
% Q
% Arg:
0
7
7
0
0
0
14
0
0
7
7
14
0
7
7
% R
% Ser:
0
0
14
7
7
0
0
40
7
14
14
7
7
14
0
% S
% Thr:
0
0
7
20
7
0
7
0
0
0
14
7
7
7
0
% T
% Val:
7
14
20
7
14
0
0
7
0
0
0
7
0
0
14
% V
% Trp:
0
0
7
0
7
0
0
0
0
0
0
0
7
0
0
% W
% Tyr:
7
7
0
0
7
14
0
0
0
0
0
7
0
27
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _